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Synthesis of cyclic peptide mimetics via the successive ring expansion of lactams

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JournalChemistry : A European Journal
DateAccepted/In press - 19 Jul 2017
DateE-pub ahead of print - 9 Aug 2017
DatePublished (current) - 27 Sep 2017
Issue number54
Volume23
Number of pages5
Pages (from-to)13314-13318
Early online date9/08/17
Original languageEnglish

Abstract

A successive ring expansion protocol is reported that enables the controlled insertion of natural and non-natural amino acid fragments into lactams. Amino acids can be installed into macrocycles via an operationally simple and scalable iterative procedure, without the need for high dilution. This method is expected to be of broad utility, especially for the synthesis of medicinally important cyclic peptide mimetics.

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    Research areas

  • Journal Article, cyclic peptides, lactams, medium-sized rings, macrocycles, ring expansion, Cyclization, Amino Acids/chemistry, Peptoids/chemical synthesis, Molecular Conformation, Lactams/chemistry, Peptides, Cyclic/chemistry

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