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Synthesis of Hetero-bifunctional, End-Capped Oligo-EDOT Derivatives

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Publication details

DateAccepted/In press - 9 Dec 2016
DatePublished (current) - 12 Jan 2017
Issue number1
Number of pages14
Pages (from-to)125-138
Original languageEnglish


Conjugated oligomers of 3,4-ethylenedioxythiophene (EDOT) are attractive materials for tissue engineering applications and as model systems for studying the properties of the widely used polymer poly(3,4-ethylenedioxythiophene). We report here the facile synthesis of a series of keto-acid end-capped oligo-EDOT derivatives (n = 2–7) through a combination of a glyoxylation end-capping strategy and iterative direct arylation chain extension. Importantly, these structures not only represent the longest oligo-EDOTs reported but are also bench stable, in contrast to previous reports on such oligomers. The constructs reported here can undergo subsequent derivatization for integration into higher-order architectures, such as those required for tissue engineering applications. The synthesis of hetero-bifunctional constructs, as well as those containing mixed-monomer units, is also reported, allowing further complexity to be installed in a controlled manner. Finally, we describe the optical and electrochemical properties of these oligomers and demonstrate the importance of the keto-acid in determining their characteristics.

Bibliographical note

© 2016 The Author(s). Published by Elsevier Inc.

    Research areas

  • C-H activation, conjugated polymer, end capping, oligomer, synthesis, thiophene

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