Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

Petr Slavík; Michal Kohout; Stanislav Böhm; Václav Eigner; Pavel Lhoták

doi:10.1039/c5cc09388k

Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

Petr Slavík, Michal Kohout, Stanislav Böhm, Václav Eigner, Pavel Lhoták^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Direct mercuration of calix[4]arene immobilized in the partial cone conformation led to the meta-substituted isomer which was subsequently subjected to Pd-catalysed coupling (C-H activation) with the neighbouring aromatic subunit. Regioselective mercuration thus enabled access to a novel type of inherently chiral calixarenes with a highly distorted cavity potentially applicable to the design of new chiral receptors.

Original language	English
Pages (from-to)	2366-2369
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	11
Early online date	21 Dec 2015
DOIs	https://doi.org/10.1039/c5cc09388k
Publication status	Published - 7 Feb 2016

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abstract = "Direct mercuration of calix[4]arene immobilized in the partial cone conformation led to the meta-substituted isomer which was subsequently subjected to Pd-catalysed coupling (C-H activation) with the neighbouring aromatic subunit. Regioselective mercuration thus enabled access to a novel type of inherently chiral calixarenes with a highly distorted cavity potentially applicable to the design of new chiral receptors.",

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AU - Slavík, Petr

AU - Kohout, Michal

AU - Böhm, Stanislav

AU - Eigner, Václav

AU - Lhoták, Pavel

PY - 2016/2/7

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AB - Direct mercuration of calix[4]arene immobilized in the partial cone conformation led to the meta-substituted isomer which was subsequently subjected to Pd-catalysed coupling (C-H activation) with the neighbouring aromatic subunit. Regioselective mercuration thus enabled access to a novel type of inherently chiral calixarenes with a highly distorted cavity potentially applicable to the design of new chiral receptors.

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DO - 10.1039/c5cc09388k

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VL - 52

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JO - Chemical Communications

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ER -

Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

Abstract

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