Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

Petr Slavík, Michal Kohout, Stanislav Böhm, Václav Eigner, Pavel Lhoták*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Direct mercuration of calix[4]arene immobilized in the partial cone conformation led to the meta-substituted isomer which was subsequently subjected to Pd-catalysed coupling (C-H activation) with the neighbouring aromatic subunit. Regioselective mercuration thus enabled access to a novel type of inherently chiral calixarenes with a highly distorted cavity potentially applicable to the design of new chiral receptors.

Original languageEnglish
Pages (from-to)2366-2369
Number of pages4
JournalChemical Communications
Issue number11
Early online date21 Dec 2015
Publication statusPublished - 7 Feb 2016

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