Abstract
The synthesis of jaspaquinol 1, a monocyclic diterpene-benzenoid, is reported. Two synthetic routes to this natural product have been developed. The first, utilises a difunctional terpene derivative containing different leaving groups, facilitating the selective introduction of the cyclohexenyl and benzenoid fragments. The alternative route employs a regiospecific Stille cross-coupling reaction to introduce the cyclohexenyl fragment, which occurs without allylic transposition. Preliminary data shows the cell viability of 1 against normal and malignant human bladder epithelial cell lines. (C) 2004 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 2883-2887 |
Number of pages | 5 |
Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 14 |
Issue number | 11 |
DOIs | |
Publication status | Published - 7 Jun 2004 |
Keywords
- SQUALENE SYNTHASE
- FARNESOL ANALOGS
- SELENIUM DIOXIDE
- THP ETHERS
- INHIBITORS
- FARNESYLTRANSFERASE
- REACTIVITY
- ALKYLATION
- OXIDATION
- COMPLEXES