SYNTHESIS OF (+)-LEUKOTRIENE B-4 (LTB4) METHYL-ESTER AND (-)-(5R)-LTB4 METHYL-ESTER VIA PYRYLIUM METHODOLOGY

B C  BORER; R J K  TAYLOR

SYNTHESIS OF (+)-LEUKOTRIENE B-4 (LTB4) METHYL-ESTER AND (-)-(5R)-LTB4 METHYL-ESTER VIA PYRYLIUM METHODOLOGY

Chemistry

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The title compounds (5S)- and (5R)-leukotriene B4 methyl esters (1) and (2), have been prepared from 3-nonenal by a short convergent synthetic route which utilises addition of 3-(tert-butyldimethylsiloxy)-1,5-undecadienyllithium (8) to pyrylium tetrafluoroborate for the construction of the crucial Z,E,E-triene unit.

Original language	English
Pages (from-to)	117-118
Number of pages	2
Journal	Synlett
Issue number	2
Publication status	Published - Feb 1992

Keywords

ANALOGS

Cite this

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title = "SYNTHESIS OF (+)-LEUKOTRIENE B-4 (LTB4) METHYL-ESTER AND (-)-(5R)-LTB4 METHYL-ESTER VIA PYRYLIUM METHODOLOGY",

abstract = "The title compounds (5S)- and (5R)-leukotriene B4 methyl esters (1) and (2), have been prepared from 3-nonenal by a short convergent synthetic route which utilises addition of 3-(tert-butyldimethylsiloxy)-1,5-undecadienyllithium (8) to pyrylium tetrafluoroborate for the construction of the crucial Z,E,E-triene unit.",

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author = "BORER, {B C} and TAYLOR, {R J K}",

year = "1992",

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language = "English",

pages = "117--118",

journal = "Synlett",

issn = "1437-2096",

publisher = "Georg Thieme Verlag",

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AU - BORER, B C

AU - TAYLOR, R J K

PY - 1992/2

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N2 - The title compounds (5S)- and (5R)-leukotriene B4 methyl esters (1) and (2), have been prepared from 3-nonenal by a short convergent synthetic route which utilises addition of 3-(tert-butyldimethylsiloxy)-1,5-undecadienyllithium (8) to pyrylium tetrafluoroborate for the construction of the crucial Z,E,E-triene unit.

AB - The title compounds (5S)- and (5R)-leukotriene B4 methyl esters (1) and (2), have been prepared from 3-nonenal by a short convergent synthetic route which utilises addition of 3-(tert-butyldimethylsiloxy)-1,5-undecadienyllithium (8) to pyrylium tetrafluoroborate for the construction of the crucial Z,E,E-triene unit.

KW - ANALOGS

M3 - Comment/debate

SN - 1437-2096

SP - 117

EP - 118

JO - Synlett

JF - Synlett

IS - 2

ER -