Research output: Contribution to journal › Article
Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives
1.91 MB, PDF document
Journal | ACS Central Science |
---|---|
Date | Accepted/In press - 28 Jan 2020 |
Date | Published (current) - 26 Feb 2020 |
Issue number | 2 |
Volume | 6 |
Number of pages | 6 |
Pages (from-to) | 226-231 |
Original language | English |
In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength.
© 2020 American Chemical Society. This is an open access article published under an ACS Author Choice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
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