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From the same journal

Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives

Research output: Contribution to journalArticle

Author(s)

  • Christopher D. Spicer
  • Michael Pujari-Palmer
  • Hélène Autefage
  • Gerard Insley
  • Philip Procter
  • Håkan Engqvist
  • Molly M. Stevens

Department/unit(s)

Publication details

JournalACS Central Science
DateAccepted/In press - 28 Jan 2020
DatePublished (current) - 26 Feb 2020
Issue number2
Volume6
Number of pages6
Pages (from-to)226-231
Original languageEnglish

Abstract

In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength.

Bibliographical note

© 2020 American Chemical Society. This is an open access article published under an ACS Author Choice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

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