Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade

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Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynone-tethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives.

Original languageEnglish
Article number131392
Issue number35
Early online date12 Jul 2020
Publication statusPublished - 28 Aug 2020

Bibliographical note

© Elsevier B. V., 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.


  • Akuammiline alkaloids
  • Cascade reactions
  • Dearomatisation
  • Indole
  • Ynones

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