Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade

TY - JOUR

T1 - Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade

AU - Clarke, Aimee K.

AU - Rossi-Ashton, James A.

AU - Taylor, Richard J.K.

AU - Unsworth, William P.

N1 - © Elsevier B. V., 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.

PY - 2020/8/28

Y1 - 2020/8/28

N2 - Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynone-tethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives.

AB - Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynone-tethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives.

KW - Akuammiline alkaloids

KW - Cascade reactions

KW - Dearomatisation

KW - Indole

KW - Ynones

UR - http://www.scopus.com/inward/record.url?scp=85088098730&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2020.131392

DO - 10.1016/j.tet.2020.131392

M3 - Article

AN - SCOPUS:85088098730

SN - 0040-4020

VL - 76

JO - Tetrahedron

JF - Tetrahedron

IS - 35

M1 - 131392

ER -