This Review provides an in-depth account of the synthesis of spirocyclic indolenines. Over the last 77 years, a wide array of diverse synthetic methods has been developed in order to generate these synthetically useful and biologically important spirocyclic scaffolds. The main synthetic strategies discussed are grouped into three main categories, namely interrupted Fischer indolisations, dearomatisation reactions of indoles and condensation reactions. The historical background, common synthetic challenges, current state-of-the-art and future perspectives of this field are examined. Another round: A detailed account of spirocyclic indolenine synthesis over the last 77 years is provided. The synthetic strategies described include interrupted Fischer indolisations, dearomatisation reactions of indoles and condensation reactions, as well miscellaneous processes. Common synthetic challenges associated with these strategies are also examined.
|Number of pages||26|
|Journal||Chemistry : A European Journal (Weinheim an der Bergstrasse, Germany)|
|Early online date||14 Dec 2015|
|Publication status||Published - 24 Feb 2016|
Bibliographical note© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Accepted 13/10/15