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From the same journal

Synthesis of Spirocyclic Indolenines

Research output: Contribution to journalReview articlepeer-review

Published copy (DOI)



Publication details

JournalChemistry : A European Journal (Weinheim an der Bergstrasse, Germany)
DateE-pub ahead of print - 14 Dec 2015
DatePublished (current) - 24 Feb 2016
Issue number9
Number of pages26
Pages (from-to)2856–2881
Early online date14/12/15
Original languageEnglish


This Review provides an in-depth account of the synthesis of spirocyclic indolenines. Over the last 77 years, a wide array of diverse synthetic methods has been developed in order to generate these synthetically useful and biologically important spirocyclic scaffolds. The main synthetic strategies discussed are grouped into three main categories, namely interrupted Fischer indolisations, dearomatisation reactions of indoles and condensation reactions. The historical background, common synthetic challenges, current state-of-the-art and future perspectives of this field are examined. Another round: A detailed account of spirocyclic indolenine synthesis over the last 77 years is provided. The synthetic strategies described include interrupted Fischer indolisations, dearomatisation reactions of indoles and condensation reactions, as well miscellaneous processes. Common synthetic challenges associated with these strategies are also examined.

Bibliographical note

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Accepted 13/10/15

    Research areas

  • 3H-indoles, Dearomatisation, Indolenines, Spirocycles, Spiroindolenines

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