Projects per year
Abstract
The short syntheses of each of the mono-acetates of N-acetyl-D-neuraminic acid are reported. These are important molecules for studying the mechanism and function of enzymes which utilise Neu5Ac as a substrate. However, until now these molecules were not available as pure compounds and instead had to be studied as mixtures. Neu4,5Ac(2) and Neu5,8Ac(2) were synthesised from a common precursor in 2 and 4 steps respectively, while Neu2,4Ac(2) and Neu5,7Ac(2) were synthesised in 3 and 4 steps respectively from another common precursor. Both precursors could be easily prepared in 3 steps from Neu5Ac itself. Importantly, no scrambling of the anomeric stereochemistry was detected throughout the course of these syntheses.
Original language | English |
---|---|
Pages (from-to) | 529-35 |
Number of pages | 7 |
Journal | Organic & biomolecular chemistry |
Volume | 10 |
Issue number | 3 |
DOIs | |
Publication status | Published - 21 Jan 2012 |
Projects
- 1 Finished
-
Synthesis of sialic acid analogues to target bacterial pathogens
Clarke, P. A., Thomas, G. H. & Mistry, N.
1/06/11 → 31/12/11
Project: Other project › Research collaboration