Synthesis of the integrastatin nucleus using the Ramberg-Bilcklund reaction

J S  Foot; G M P  Giblin; R J K  Taylor

doi:10.1021/ol035786v

Synthesis of the integrastatin nucleus using the Ramberg-Bilcklund reaction

J S Foot, G M P Giblin, R J K Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Backlund reaction and an unusual Lewis acid-promoted cyclization step.

Original language	English
Pages (from-to)	4441-4444
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	23
DOIs	https://doi.org/10.1021/ol035786v
Publication status	Published - 13 Nov 2003

Keywords

REAGENT

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10.1021/ol035786v

Cite this

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title = "Synthesis of the integrastatin nucleus using the Ramberg-Bilcklund reaction",

abstract = "The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Backlund reaction and an unusual Lewis acid-promoted cyclization step.",

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AB - The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Backlund reaction and an unusual Lewis acid-promoted cyclization step.

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