SYNTHESIS OF THE NOVEL ANTILEUKEMIC TETRAHYDROCYCLOPENTA[B]BENZOFURAN, ROCAGLAMIDE

A E  DAVEY; M J  SCHAEFFER; R J K  TAYLOR

SYNTHESIS OF THE NOVEL ANTILEUKEMIC TETRAHYDROCYCLOPENTA[B]BENZOFURAN, ROCAGLAMIDE

A E DAVEY, M J SCHAEFFER, R J K TAYLOR

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A total synthesis of the novel anti-leukaemic natural product, rocaglamide, in racemic form, is described, the key step involving an intramolecular keto-aldehyde pinacolic coupling; the synthetic route is short, proceeds from phloroglucinol, a readily-available starting material, and is well suited to the synthesis of analogues.

Original language	English
Pages (from-to)	1137-1139
Number of pages	3
Journal	JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS
Issue number	16
Publication status	Published - 15 Aug 1991

Keywords

CYCLIZATION
KETONES

Cite this

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title = "SYNTHESIS OF THE NOVEL ANTILEUKEMIC TETRAHYDROCYCLOPENTA[B]BENZOFURAN, ROCAGLAMIDE",

abstract = "A total synthesis of the novel anti-leukaemic natural product, rocaglamide, in racemic form, is described, the key step involving an intramolecular keto-aldehyde pinacolic coupling; the synthetic route is short, proceeds from phloroglucinol, a readily-available starting material, and is well suited to the synthesis of analogues.",

keywords = "CYCLIZATION, KETONES",

author = "DAVEY, {A E} and SCHAEFFER, {M J} and TAYLOR, {R J K}",

year = "1991",

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journal = "JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS",

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AU - TAYLOR, R J K

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N2 - A total synthesis of the novel anti-leukaemic natural product, rocaglamide, in racemic form, is described, the key step involving an intramolecular keto-aldehyde pinacolic coupling; the synthetic route is short, proceeds from phloroglucinol, a readily-available starting material, and is well suited to the synthesis of analogues.

AB - A total synthesis of the novel anti-leukaemic natural product, rocaglamide, in racemic form, is described, the key step involving an intramolecular keto-aldehyde pinacolic coupling; the synthetic route is short, proceeds from phloroglucinol, a readily-available starting material, and is well suited to the synthesis of analogues.

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KW - KETONES

M3 - Article

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JO - JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS

JF - JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS

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