Abstract
4-Hydroxycyclohex-2-en-1-one and its derivatives have been used as the key chiral building blocks in a number of natural product and complex molecule syntheses. This review describes the many and varied methods for preparing the title compound in an enantioselective manner and also details how it has been utilised in natural product synthesis.
Original language | English |
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Pages (from-to) | 681-707 |
Number of pages | 27 |
Journal | SYNTHESIS-STUTTGART |
Issue number | 5 |
DOIs | |
Publication status | Published - Mar 2011 |
Keywords
- asymmetric catalysis
- chiral auxiliaries
- chiral pool
- kinetic resolution
- natural products
- BACTERIAL-DNA PRIMASE
- ALKYLIDENE-GAMMA-BUTYROLACTONES
- ENANTIOSELECTIVE SYNTHESIS
- STEREOSELECTIVE-SYNTHESIS
- ABSOLUTE-CONFIGURATION
- CONCISE SYNTHESIS
- MICHAEL REACTION
- BLENNOLIDE-C
- EFFICIENT
- INHIBITOR