Synthetic approaches to pallimamine and analogues using direct imine acylation

Thomas O. Ronson, Christiana Kitsiou, William P. Unsworth*, Richard J K Taylor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The use of Direct Imine Acylation (DIA) methodology for the total synthesis of pallimamine is described, with three different synthetic routes examined. The construction of three advanced δ-lactam precursors, all utilising DIA, is described, along with attempts to progress these compounds further, using three distinct desymmetrisation strategies, two involving alcohol-aryl coupling, and a third involving an unusual diastereoselective lactonisation.

Original languageEnglish
Number of pages8
Early online date13 May 2016
Publication statusE-pub ahead of print - 13 May 2016

Bibliographical note

© 2016 The Authors.


  • Berberine alkaloids
  • Imines
  • N-acyliminium ions
  • Nitrogen heterocycles
  • Pallimamine

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