Synthetic biology approaches to actinomycete strain improvement

Rainer Breitling, Martina Avbelj, Oksana Bilyk, Francesco Del Carratore, Alessandro Filisetti, Erik K.R. Hanko, Marianna Iorio, Rosario Pérez Redondo, Fernando Reyes, Michelle Rudden, Emmanuele Severi, Lucija Slemc, Kamila Schmidt, Dominic R. Whittall, Stefano Donadio, Antonio Rodríguez García, Olga Genilloud, Gregor Kosec, Davide De Lucrezia, Hrvoje PetkovićGavin Thomas, Eriko Takano*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

Original languageEnglish
Article numberfnab060
Number of pages9
JournalFEMS microbiology letters
Issue number10
Publication statusPublished - 31 May 2021

Bibliographical note

Funding Information:
This review was funded through the European Union s Horizon 2020 Research and Innovation Programme under grant agreement number 720793 TOPCAPI

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.


  • Actinobacteria
  • Actinomycete
  • Biosynthesis
  • Biotechnology
  • Synthetic biology

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