Synthetically accessible, high-affinity phosphate anion receptors

Hubertus (Bart) F. M. Nelissen; David K. Smith

doi:10.1039/b706227c

Synthetically accessible, high-affinity phosphate anion receptors

Hubertus (Bart) F. M. Nelissen, David K. Smith

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We report synthetically accessible receptors with protonated amines attached to a conformationally constrained backbone including amide units, and demonstrate that these receptors have high affinities (log K > 5) for phosphate anions in aqueous media at pH 7 in the presence of high concentrations of competitive chloride anions (ca. 100-fold excess).

Original language	English
Pages (from-to)	3039-3041
Number of pages	3
Journal	Chemical Communications
Issue number	29
DOIs	https://doi.org/10.1039/b706227c
Publication status	Published - 2007

Keywords

6-AMINOPICOLINIC ACID SUBUNITS
AQUEOUS-SOLUTION
ELECTROCHEMICAL RECOGNITION
MACROCYCLIC LIGANDS
BINDING PROPERTIES
POLYAMINES
SULFATE
NUCLEOTIDES
WATER

Access to Document

10.1039/b706227c

Cite this

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title = "Synthetically accessible, high-affinity phosphate anion receptors",

abstract = "We report synthetically accessible receptors with protonated amines attached to a conformationally constrained backbone including amide units, and demonstrate that these receptors have high affinities (log K > 5) for phosphate anions in aqueous media at pH 7 in the presence of high concentrations of competitive chloride anions (ca. 100-fold excess).",

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author = "Nelissen, {Hubertus (Bart) F. M.} and Smith, {David K.}",

year = "2007",

doi = "10.1039/b706227c",

language = "English",

pages = "3039--3041",

journal = "Chemical Communications",

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publisher = "The Royal Society of Chemistry",

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AU - Nelissen, Hubertus (Bart) F. M.

AU - Smith, David K.

PY - 2007

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AB - We report synthetically accessible receptors with protonated amines attached to a conformationally constrained backbone including amide units, and demonstrate that these receptors have high affinities (log K > 5) for phosphate anions in aqueous media at pH 7 in the presence of high concentrations of competitive chloride anions (ca. 100-fold excess).

KW - 6-AMINOPICOLINIC ACID SUBUNITS

KW - AQUEOUS-SOLUTION

KW - ELECTROCHEMICAL RECOGNITION

KW - MACROCYCLIC LIGANDS

KW - BINDING PROPERTIES

KW - POLYAMINES

KW - SULFATE

KW - NUCLEOTIDES

KW - WATER

U2 - 10.1039/b706227c

DO - 10.1039/b706227c

M3 - Article

SN - 1359-7345

SP - 3039

EP - 3041

JO - Chemical Communications

JF - Chemical Communications

IS - 29

ER -