Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups

Jane Burch; Stephen Rice; Huiqin Yang; Aileen Neilson; Lisa Stirk; Roger Francis; Paul Holloway; Peter Selby; Dawn Craig

doi:10.3310/hta18110

Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups

Jane Burch, Stephen Rice, Huiqin Yang, Aileen Neilson, Lisa Stirk, Roger Francis, Paul Holloway, Peter Selby, Dawn Craig

Centre for Reviews and Dissemination

Research output: Contribution to journal › Article › peer-review

Abstract

There is currently no standard practice for the monitoring of patients receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is commonly used for monitoring treatment response, but it has its limitations. Bone turnover markers have advantages over DXA as they are non-invasive, relatively cheap and can detect changes in bone turnover rates earlier. However, they do have disadvantages, particularly high within- and between-patient variability. The ability of bone turnover markers to identify treatment non-responders and predict future fracture risk has yet to be established.

Original language	English
Pages (from-to)	1-180
Number of pages	180
Journal	Health technology assessment
Volume	18
Issue number	11
DOIs	https://doi.org/10.3310/hta18110
Publication status	Published - Feb 2014

Access to Document

10.3310/hta18110

Cite this

Burch, J., Rice, S., Yang, H., Neilson, A., Stirk, L., Francis, R., Holloway, P., Selby, P., & Craig, D. (2014). Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups. Health technology assessment, 18(11), 1-180. https://doi.org/10.3310/hta18110

@article{efb0ace430da4628802decf7f8d27a31,

title = "Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups",

abstract = "There is currently no standard practice for the monitoring of patients receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is commonly used for monitoring treatment response, but it has its limitations. Bone turnover markers have advantages over DXA as they are non-invasive, relatively cheap and can detect changes in bone turnover rates earlier. However, they do have disadvantages, particularly high within- and between-patient variability. The ability of bone turnover markers to identify treatment non-responders and predict future fracture risk has yet to be established.",

author = "Jane Burch and Stephen Rice and Huiqin Yang and Aileen Neilson and Lisa Stirk and Roger Francis and Paul Holloway and Peter Selby and Dawn Craig",

year = "2014",

month = feb,

doi = "10.3310/hta18110",

language = "English",

volume = "18",

pages = "1--180",

journal = "Health technology assessment",

issn = "2046-4924",

publisher = "NHS National Institute for Health Research",

number = "11",

}

Burch, J , Rice, S , Yang, H , Neilson, A, Stirk, L, Francis, R, Holloway, P, Selby, P & Craig, D 2014, 'Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups', Health technology assessment, vol. 18, no. 11, pp. 1-180. https://doi.org/10.3310/hta18110

Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups. / Burch, Jane ; Rice, Stephen ; Yang, Huiqin et al.
In: Health technology assessment, Vol. 18, No. 11, 02.2014, p. 1-180.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment

T2 - the secondary prevention of fractures, and primary prevention of fractures in high-risk groups

AU - Burch, Jane

AU - Rice, Stephen

AU - Yang, Huiqin

AU - Neilson, Aileen

AU - Stirk, Lisa

AU - Francis, Roger

AU - Holloway, Paul

AU - Selby, Peter

AU - Craig, Dawn

PY - 2014/2

Y1 - 2014/2

N2 - There is currently no standard practice for the monitoring of patients receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is commonly used for monitoring treatment response, but it has its limitations. Bone turnover markers have advantages over DXA as they are non-invasive, relatively cheap and can detect changes in bone turnover rates earlier. However, they do have disadvantages, particularly high within- and between-patient variability. The ability of bone turnover markers to identify treatment non-responders and predict future fracture risk has yet to be established.

AB - There is currently no standard practice for the monitoring of patients receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is commonly used for monitoring treatment response, but it has its limitations. Bone turnover markers have advantages over DXA as they are non-invasive, relatively cheap and can detect changes in bone turnover rates earlier. However, they do have disadvantages, particularly high within- and between-patient variability. The ability of bone turnover markers to identify treatment non-responders and predict future fracture risk has yet to be established.

U2 - 10.3310/hta18110

DO - 10.3310/hta18110

M3 - Article

C2 - 24534414

SN - 2046-4924

VL - 18

SP - 1

EP - 180

JO - Health technology assessment

JF - Health technology assessment

IS - 11

ER -