Systematic review of the use of bone turnover markers for monitoring the response to osteoporosis treatment: the secondary prevention of fractures, and primary prevention of fractures in high-risk groups

Jane Burch, Stephen Rice, Huiqin Yang, Aileen Neilson, Lisa Stirk, Roger Francis, Paul Holloway, Peter Selby, Dawn Craig

Research output: Contribution to journalArticlepeer-review


There is currently no standard practice for the monitoring of patients receiving treatment for osteoporosis. Repeated dual-energy X-ray absorptiometry (DXA) is commonly used for monitoring treatment response, but it has its limitations. Bone turnover markers have advantages over DXA as they are non-invasive, relatively cheap and can detect changes in bone turnover rates earlier. However, they do have disadvantages, particularly high within- and between-patient variability. The ability of bone turnover markers to identify treatment non-responders and predict future fracture risk has yet to be established.
Original languageEnglish
Pages (from-to)1-180
Number of pages180
JournalHealth technology assessment
Issue number11
Publication statusPublished - Feb 2014

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