Tandem Meinwald Rearrangement-Fischer Indolisation: A One-Pot Conversion of Epoxides into Indoles

James R. Donald, Richard J. K. Taylor

Research output: Contribution to journalArticlepeer-review

Abstract

A tandem Sc(OTf)(3)-mediated Meinwald epoxide rearrangement-Fischer indole synthesis is reported. Optimisation and scope and limitation studies are described. In addition, preliminary investigations to develop a telescoped epoxidation-Meinwald rearrangement-Fischer indole sequence are outlined.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalSynlett
Issue number1
DOIs
Publication statusPublished - 2 Jan 2009

Keywords

  • aldehydes
  • epoxides
  • indoles
  • rearrangements
  • tandem reactions
  • ALDEHYDES
  • KETONES
  • OXIDATION
  • EFFICIENT
  • CATALYST
  • METALLOPORPHYRIN
  • ISOMERIZATION
  • CONSTRUCTION
  • DERIVATIVES

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