Tandem oxidation processes: The direct conversion of activated alcohols into nitriles

G D  McAllister; C D  Wilfred; R J K  Taylor

Tandem oxidation processes: The direct conversion of activated alcohols into nitriles

G D McAllister, C D Wilfred, R J K Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The direct conversion of primary alcohols into nitriles is reported (RCH2OH into RCN) using manganese dioxide and ammonia in 2-propanol-THF, containing magnesium sulfate at room temperature. This transformation, which proceeds via an in situ oxidation-imination-aldimine oxidation sequence, has been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.

Original language	English
Pages (from-to)	1291-1292
Number of pages	2
Journal	Synlett
Issue number	8
Publication status	Published - Aug 2002

Keywords

oxidation
imines
nitriles
cyanides
one-pot
MANGANESE-DIOXIDE
WITTIG REACTIONS

Cite this

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title = "Tandem oxidation processes: The direct conversion of activated alcohols into nitriles",

abstract = "The direct conversion of primary alcohols into nitriles is reported (RCH2OH into RCN) using manganese dioxide and ammonia in 2-propanol-THF, containing magnesium sulfate at room temperature. This transformation, which proceeds via an in situ oxidation-imination-aldimine oxidation sequence, has been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.",

keywords = "oxidation, imines, nitriles, cyanides, one-pot, MANGANESE-DIOXIDE, WITTIG REACTIONS",

author = "McAllister, {G D} and Wilfred, {C D} and Taylor, {R J K}",

year = "2002",

month = aug,

language = "English",

pages = "1291--1292",

journal = "Synlett",

issn = "1437-2096",

publisher = "Georg Thieme Verlag",

number = "8",

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TY - JOUR

T1 - Tandem oxidation processes: The direct conversion of activated alcohols into nitriles

AU - McAllister, G D

AU - Wilfred, C D

AU - Taylor, R J K

PY - 2002/8

Y1 - 2002/8

N2 - The direct conversion of primary alcohols into nitriles is reported (RCH2OH into RCN) using manganese dioxide and ammonia in 2-propanol-THF, containing magnesium sulfate at room temperature. This transformation, which proceeds via an in situ oxidation-imination-aldimine oxidation sequence, has been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.

AB - The direct conversion of primary alcohols into nitriles is reported (RCH2OH into RCN) using manganese dioxide and ammonia in 2-propanol-THF, containing magnesium sulfate at room temperature. This transformation, which proceeds via an in situ oxidation-imination-aldimine oxidation sequence, has been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.

KW - oxidation

KW - imines

KW - nitriles

KW - cyanides

KW - one-pot

KW - MANGANESE-DIOXIDE

KW - WITTIG REACTIONS

M3 - Article

SN - 1437-2096

SP - 1291

EP - 1292

JO - Synlett

JF - Synlett

IS - 8

ER -