Tandem oxidation processes: The direct conversion of activated alcohols into esters and amides

J S  Foot; H  Kanno; G M P  Giblin; R J K  Taylor

Tandem oxidation processes: The direct conversion of activated alcohols into esters and amides

J S Foot, H Kanno, G M P Giblin, R J K Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The direct conversion of primary alcohols into methyl esters and amides using manganese dioxide and sodium cyanide with methanol or the appropriate amine is reported. These transformations, which proceed via an in situ four step, double oxidation sequence, have been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.

Original language	English
Pages (from-to)	1293-1295
Number of pages	3
Journal	Synlett
Issue number	8
Publication status	Published - Aug 2002

Keywords

oxidation
cyanide
cyanchydrin
acyl cyanide
one-pot
MANGANESE-DIOXIDE
WITTIG REACTIONS

Cite this

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title = "Tandem oxidation processes: The direct conversion of activated alcohols into esters and amides",

abstract = "The direct conversion of primary alcohols into methyl esters and amides using manganese dioxide and sodium cyanide with methanol or the appropriate amine is reported. These transformations, which proceed via an in situ four step, double oxidation sequence, have been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.",

keywords = "oxidation, cyanide, cyanchydrin, acyl cyanide, one-pot, MANGANESE-DIOXIDE, WITTIG REACTIONS",

author = "Foot, {J S} and H Kanno and Giblin, {G M P} and Taylor, {R J K}",

year = "2002",

month = aug,

language = "English",

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journal = "Synlett",

issn = "1437-2096",

publisher = "Georg Thieme Verlag",

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T1 - Tandem oxidation processes: The direct conversion of activated alcohols into esters and amides

AU - Foot, J S

AU - Kanno, H

AU - Giblin, G M P

AU - Taylor, R J K

PY - 2002/8

Y1 - 2002/8

N2 - The direct conversion of primary alcohols into methyl esters and amides using manganese dioxide and sodium cyanide with methanol or the appropriate amine is reported. These transformations, which proceed via an in situ four step, double oxidation sequence, have been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.

AB - The direct conversion of primary alcohols into methyl esters and amides using manganese dioxide and sodium cyanide with methanol or the appropriate amine is reported. These transformations, which proceed via an in situ four step, double oxidation sequence, have been applied to a range of benzylic, heterocyclic, allylic and propargylic alcohols.

KW - oxidation

KW - cyanide

KW - cyanchydrin

KW - acyl cyanide

KW - one-pot

KW - MANGANESE-DIOXIDE

KW - WITTIG REACTIONS

M3 - Article

SN - 1437-2096

SP - 1293

EP - 1295

JO - Synlett

JF - Synlett

IS - 8

ER -