Tandem radical cyclisation and translocation approaches to biologically important mitomycin ring systems

G M  Allan; A F  Parsons; J F  Pons

Tandem radical cyclisation and translocation approaches to biologically important mitomycin ring systems

G M Allan, A F Parsons, J F Pons

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

New free-radical cyclisation and translocation approaches to the tricyclic mitomycin ring system have been developed. These convergent approaches involve either a tandem 5-endol-5-exo radical cyclisation or alternatively, a 1,6-hydrogen-atom transfer followed by 5-exo cyclisation sequence.

Original language	English
Pages (from-to)	1431-1434
Number of pages	4
Journal	Synlett
Issue number	9
Publication status	Published - Sep 2002

Keywords

cyclisations
mitomycin
radical reactions
tandem reactions
tin
CYCLIZATION
SUBSTITUENT
ACTIVATION
MECHANISM

Cite this

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title = "Tandem radical cyclisation and translocation approaches to biologically important mitomycin ring systems",

abstract = "New free-radical cyclisation and translocation approaches to the tricyclic mitomycin ring system have been developed. These convergent approaches involve either a tandem 5-endol-5-exo radical cyclisation or alternatively, a 1,6-hydrogen-atom transfer followed by 5-exo cyclisation sequence.",

keywords = "cyclisations, mitomycin, radical reactions, tandem reactions, tin, CYCLIZATION, SUBSTITUENT, ACTIVATION, MECHANISM",

author = "Allan, {G M} and Parsons, {A F} and Pons, {J F}",

year = "2002",

month = sep,

language = "English",

pages = "1431--1434",

journal = "Synlett",

issn = "1437-2096",

publisher = "Georg Thieme Verlag",

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AU - Allan, G M

AU - Parsons, A F

AU - Pons, J F

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N2 - New free-radical cyclisation and translocation approaches to the tricyclic mitomycin ring system have been developed. These convergent approaches involve either a tandem 5-endol-5-exo radical cyclisation or alternatively, a 1,6-hydrogen-atom transfer followed by 5-exo cyclisation sequence.

AB - New free-radical cyclisation and translocation approaches to the tricyclic mitomycin ring system have been developed. These convergent approaches involve either a tandem 5-endol-5-exo radical cyclisation or alternatively, a 1,6-hydrogen-atom transfer followed by 5-exo cyclisation sequence.

KW - cyclisations

KW - mitomycin

KW - radical reactions

KW - tandem reactions

KW - tin

KW - CYCLIZATION

KW - SUBSTITUENT

KW - ACTIVATION

KW - MECHANISM

M3 - Article

SP - 1431

EP - 1434

JO - Synlett

JF - Synlett

SN - 1437-2096

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