Tandem radical cyclisation and translocation approaches to biologically important mitomycin ring systems

G M Allan, A F Parsons, J F Pons

Research output: Contribution to journalArticlepeer-review

Abstract

New free-radical cyclisation and translocation approaches to the tricyclic mitomycin ring system have been developed. These convergent approaches involve either a tandem 5-endol-5-exo radical cyclisation or alternatively, a 1,6-hydrogen-atom transfer followed by 5-exo cyclisation sequence.

Original languageEnglish
Pages (from-to)1431-1434
Number of pages4
JournalSynlett
Issue number9
Publication statusPublished - Sept 2002

Keywords

  • cyclisations
  • mitomycin
  • radical reactions
  • tandem reactions
  • tin
  • CYCLIZATION
  • SUBSTITUENT
  • ACTIVATION
  • MECHANISM

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