Tandem radical cyclisations leading to indolizidinones and pyrrolizidinones

S R  Baker; A F  Parsons; J F  Pons; M  Wilson

Tandem radical cyclisations leading to indolizidinones and pyrrolizidinones

S R Baker, A F Parsons, J F Pons, M Wilson

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Reaction of various dehydroamino esters with tin hydrides resulted in 5-endo-5-exo or 5-endo-6-endo tandem cyclisation reactions. The preferred pathway was dependent on alkene substitution and the bicyclic products have potential application in indolizidine and pyrrolizidine alkaloid synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	7197-7200
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	39
Publication status	Published - 24 Sept 1998

Keywords

cyclisation
tin and compounds
alkaloids
bicyclic heterocyclic compounds
CYCLIZATION APPROACH
RING-CLOSURE
PYROGLUTAMATES
ACID
ALKALOIDS
LACTAMS

Cite this

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title = "Tandem radical cyclisations leading to indolizidinones and pyrrolizidinones",

abstract = "Reaction of various dehydroamino esters with tin hydrides resulted in 5-endo-5-exo or 5-endo-6-endo tandem cyclisation reactions. The preferred pathway was dependent on alkene substitution and the bicyclic products have potential application in indolizidine and pyrrolizidine alkaloid synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.",

keywords = "cyclisation, tin and compounds, alkaloids, bicyclic heterocyclic compounds, CYCLIZATION APPROACH, RING-CLOSURE, PYROGLUTAMATES, ACID, ALKALOIDS, LACTAMS",

author = "Baker, {S R} and Parsons, {A F} and Pons, {J F} and M Wilson",

year = "1998",

month = sep,

day = "24",

language = "English",

volume = "39",

pages = "7197--7200",

journal = "Tetrahedron Letters",

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T1 - Tandem radical cyclisations leading to indolizidinones and pyrrolizidinones

AU - Baker, S R

AU - Parsons, A F

AU - Pons, J F

AU - Wilson, M

PY - 1998/9/24

Y1 - 1998/9/24

N2 - Reaction of various dehydroamino esters with tin hydrides resulted in 5-endo-5-exo or 5-endo-6-endo tandem cyclisation reactions. The preferred pathway was dependent on alkene substitution and the bicyclic products have potential application in indolizidine and pyrrolizidine alkaloid synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.

AB - Reaction of various dehydroamino esters with tin hydrides resulted in 5-endo-5-exo or 5-endo-6-endo tandem cyclisation reactions. The preferred pathway was dependent on alkene substitution and the bicyclic products have potential application in indolizidine and pyrrolizidine alkaloid synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.

KW - cyclisation

KW - tin and compounds

KW - alkaloids

KW - bicyclic heterocyclic compounds

KW - CYCLIZATION APPROACH

KW - RING-CLOSURE

KW - PYROGLUTAMATES

KW - ACID

KW - ALKALOIDS

KW - LACTAMS

M3 - Article

SN - 0040-4039

VL - 39

SP - 7197

EP - 7200

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -