Tandem retro-aldol/Wittig/Michael and related cascade processes

Sandra Beltran-Rodil; James R. Donald; Michael G. Edwards; Steven A. Raw; Richard J. K. Taylor

doi:10.1016/j.tetlet.2009.02.115

Tandem retro-aldol/Wittig/Michael and related cascade processes

Sandra Beltran-Rodil, James R. Donald, Michael G. Edwards, Steven A. Raw, Richard J. K. Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/intramolecular Michael addition and (iv) retro-aldol/Knoevenagel/intramolecular Michael addition sequences. A range of novel functionalised cyclopentanes, and related systems, are described which should prove to be useful synthetic building blocks. (C) 2009 Elsevier Ltd. All Fights reserved.

Original language	English
Pages (from-to)	3378-3380
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2009.02.115
Publication status	Published - 1 Jul 2009

Keywords

OXIDATION PROCESSES
SEQUENCES

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10.1016/j.tetlet.2009.02.115

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title = "Tandem retro-aldol/Wittig/Michael and related cascade processes",

abstract = "A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/intramolecular Michael addition and (iv) retro-aldol/Knoevenagel/intramolecular Michael addition sequences. A range of novel functionalised cyclopentanes, and related systems, are described which should prove to be useful synthetic building blocks. (C) 2009 Elsevier Ltd. All Fights reserved.",

keywords = "OXIDATION PROCESSES, SEQUENCES",

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year = "2009",

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T1 - Tandem retro-aldol/Wittig/Michael and related cascade processes

AU - Beltran-Rodil, Sandra

AU - Donald, James R.

AU - Edwards, Michael G.

AU - Raw, Steven A.

AU - Taylor, Richard J. K.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/intramolecular Michael addition and (iv) retro-aldol/Knoevenagel/intramolecular Michael addition sequences. A range of novel functionalised cyclopentanes, and related systems, are described which should prove to be useful synthetic building blocks. (C) 2009 Elsevier Ltd. All Fights reserved.

AB - A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/intramolecular Michael addition and (iv) retro-aldol/Knoevenagel/intramolecular Michael addition sequences. A range of novel functionalised cyclopentanes, and related systems, are described which should prove to be useful synthetic building blocks. (C) 2009 Elsevier Ltd. All Fights reserved.

KW - OXIDATION PROCESSES

KW - SEQUENCES

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U2 - 10.1016/j.tetlet.2009.02.115

DO - 10.1016/j.tetlet.2009.02.115

M3 - Article

SN - 0040-4039

VL - 50

SP - 3378

EP - 3380

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

Tandem retro-aldol/Wittig/Michael and related cascade processes

Abstract

Keywords

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