Tandem retro-aldol/Wittig/Michael and related cascade processes

TY - JOUR

T1 - Tandem retro-aldol/Wittig/Michael and related cascade processes

AU - Beltran-Rodil, Sandra

AU - Donald, James R.

AU - Edwards, Michael G.

AU - Raw, Steven A.

AU - Taylor, Richard J. K.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/intramolecular Michael addition and (iv) retro-aldol/Knoevenagel/intramolecular Michael addition sequences. A range of novel functionalised cyclopentanes, and related systems, are described which should prove to be useful synthetic building blocks. (C) 2009 Elsevier Ltd. All Fights reserved.

AB - A number of novel tandem sequences initiated by a retro-aldol process are described along with preliminary scope and limitation studies. These include (i) retro-aldol/Wittig trapping/intramolecular Michael addition, (ii) retro-aldol/aza-Wittig/intramolecular imine addition, (iii) retro-aldol/Henry/intramolecular Michael addition and (iv) retro-aldol/Knoevenagel/intramolecular Michael addition sequences. A range of novel functionalised cyclopentanes, and related systems, are described which should prove to be useful synthetic building blocks. (C) 2009 Elsevier Ltd. All Fights reserved.

KW - OXIDATION PROCESSES

KW - SEQUENCES

UR - http://www.scopus.com/inward/record.url?scp=65549088073&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2009.02.115

DO - 10.1016/j.tetlet.2009.02.115

M3 - Article

SN - 0040-4039

VL - 50

SP - 3378

EP - 3380

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -