By the same authors

From the same journal

Targeting therapeutic gene expression to human prostate cancers

Research output: Contribution to journalLiterature review

Author(s)

Department/unit(s)

Publication details

JournalCurrent opinion in molecular therapeutics
DatePublished - Aug 2000
Issue number4
Volume2
Number of pages11
Pages (from-to)389-399
Original languageEnglish

Abstract

Most current therapies against human carcinoma of the prostate are palliative rather than curative. Thus, there is a pressing need for new therapies directed against this common tumor, based on knowledge of the basic biology of the prostate, rather than by extrapolation of treatments from other tumor types. This review presents the various levels of prostate targeting which could be and have been applied, at the attachment, expression and therapeutic gene levels to eliminate prostate carcinoma cells in extraprostatic sires. To achieve optimal and safe targeting, a combination approach will be necessary, as there are few genes whose expression call provide absolute prostate specificity.

    Research areas

  • gene targeting, prostatic cancer, specificity, ANDROGEN-REGULATED EXPRESSION, RECOMBINANT ADENOVIRUS VECTOR, MEMBRANE ANTIGEN EXPRESSION, GROWTH-FACTOR RECEPTORS, MONOCLONAL-ANTIBODY, CARCINOMA-CELLS, IN-VIVO, INTRAEPITHELIAL NEOPLASIA, CLINICAL-TRIAL, STEROID 5-ALPHA-REDUCTASE

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations