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From the same journal

Targeting therapeutic gene expression to human prostate cancers

Research output: Contribution to journalLiterature reviewpeer-review

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Targeting therapeutic gene expression to human prostate cancers. / Maitland, N J.

In: Current opinion in molecular therapeutics, Vol. 2, No. 4, 08.2000, p. 389-399.

Research output: Contribution to journalLiterature reviewpeer-review

Harvard

Maitland, NJ 2000, 'Targeting therapeutic gene expression to human prostate cancers', Current opinion in molecular therapeutics, vol. 2, no. 4, pp. 389-399.

APA

Maitland, N. J. (2000). Targeting therapeutic gene expression to human prostate cancers. Current opinion in molecular therapeutics, 2(4), 389-399.

Vancouver

Maitland NJ. Targeting therapeutic gene expression to human prostate cancers. Current opinion in molecular therapeutics. 2000 Aug;2(4):389-399.

Author

Maitland, N J. / Targeting therapeutic gene expression to human prostate cancers. In: Current opinion in molecular therapeutics. 2000 ; Vol. 2, No. 4. pp. 389-399.

Bibtex - Download

@article{b9da7517605e40ceb50b3322501da070,
title = "Targeting therapeutic gene expression to human prostate cancers",
abstract = "Most current therapies against human carcinoma of the prostate are palliative rather than curative. Thus, there is a pressing need for new therapies directed against this common tumor, based on knowledge of the basic biology of the prostate, rather than by extrapolation of treatments from other tumor types. This review presents the various levels of prostate targeting which could be and have been applied, at the attachment, expression and therapeutic gene levels to eliminate prostate carcinoma cells in extraprostatic sires. To achieve optimal and safe targeting, a combination approach will be necessary, as there are few genes whose expression call provide absolute prostate specificity.",
keywords = "gene targeting, prostatic cancer, specificity, ANDROGEN-REGULATED EXPRESSION, RECOMBINANT ADENOVIRUS VECTOR, MEMBRANE ANTIGEN EXPRESSION, GROWTH-FACTOR RECEPTORS, MONOCLONAL-ANTIBODY, CARCINOMA-CELLS, IN-VIVO, INTRAEPITHELIAL NEOPLASIA, CLINICAL-TRIAL, STEROID 5-ALPHA-REDUCTASE",
author = "Maitland, {N J}",
year = "2000",
month = aug,
language = "English",
volume = "2",
pages = "389--399",
journal = "Current opinion in molecular therapeutics",
issn = "1464-8431",
publisher = "Current Drugs Ltd.",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Targeting therapeutic gene expression to human prostate cancers

AU - Maitland, N J

PY - 2000/8

Y1 - 2000/8

N2 - Most current therapies against human carcinoma of the prostate are palliative rather than curative. Thus, there is a pressing need for new therapies directed against this common tumor, based on knowledge of the basic biology of the prostate, rather than by extrapolation of treatments from other tumor types. This review presents the various levels of prostate targeting which could be and have been applied, at the attachment, expression and therapeutic gene levels to eliminate prostate carcinoma cells in extraprostatic sires. To achieve optimal and safe targeting, a combination approach will be necessary, as there are few genes whose expression call provide absolute prostate specificity.

AB - Most current therapies against human carcinoma of the prostate are palliative rather than curative. Thus, there is a pressing need for new therapies directed against this common tumor, based on knowledge of the basic biology of the prostate, rather than by extrapolation of treatments from other tumor types. This review presents the various levels of prostate targeting which could be and have been applied, at the attachment, expression and therapeutic gene levels to eliminate prostate carcinoma cells in extraprostatic sires. To achieve optimal and safe targeting, a combination approach will be necessary, as there are few genes whose expression call provide absolute prostate specificity.

KW - gene targeting

KW - prostatic cancer

KW - specificity

KW - ANDROGEN-REGULATED EXPRESSION

KW - RECOMBINANT ADENOVIRUS VECTOR

KW - MEMBRANE ANTIGEN EXPRESSION

KW - GROWTH-FACTOR RECEPTORS

KW - MONOCLONAL-ANTIBODY

KW - CARCINOMA-CELLS

KW - IN-VIVO

KW - INTRAEPITHELIAL NEOPLASIA

KW - CLINICAL-TRIAL

KW - STEROID 5-ALPHA-REDUCTASE

M3 - Literature review

VL - 2

SP - 389

EP - 399

JO - Current opinion in molecular therapeutics

JF - Current opinion in molecular therapeutics

SN - 1464-8431

IS - 4

ER -