The ‘allosteron’ model for entropic allostery of self-assembly

Tom McLeish*, C. Schaefer, A. C. von der Heydt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Using the simple ‘allosteron’ model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families. This article is part of a discussion meeting issue ‘Allostery and molecular machines’.

Original languageEnglish
Article number20170186
Number of pages8
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1749
Early online date7 May 2018
Publication statusPublished - 19 Jun 2018

Bibliographical note

© 2018 The Author(s)


  • Allostery
  • Ligand-binding
  • Self-assembly

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