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The ‘allosteron’ model for entropic allostery of self-assembly
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Publication details
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
|---|---|
| Date | Accepted/In press - 15 Feb 2018 |
| Date | E-pub ahead of print - 7 May 2018 |
| Date | Published (current) - 19 Jun 2018 |
| Issue number | 1749 |
| Volume | 373 |
| Number of pages | 8 |
| Early online date | 7/05/18 |
| Original language | English |
Abstract
Using the simple ‘allosteron’ model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families. This article is part of a discussion meeting issue ‘Allostery and molecular machines’.
Bibliographical note
© 2018 The Author(s)
- Allostery, Ligand-binding, Self-assembly
Research areas
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