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From the same journal

The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

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Published copy (DOI)

Author(s)

  • Antony N. Dodd
  • Michael J. Gardner
  • Carlos T. Hotta
  • Katharine E. Hubbard
  • Neil Dalchau
  • John Love
  • Jean-Maurice Assie
  • Fiona C. Robertson
  • Mia Kyed Jakobsen
  • Jorge Goncalves
  • Dale Sanders
  • Alex A. R. Webb

Department/unit(s)

Publication details

JournalScience
DatePublished - 14 Dec 2007
Issue number5857
Volume318
Number of pages4
Pages (from-to)1789-1792
Original languageEnglish

Abstract

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.

    Research areas

  • CYCLIC ADP-RIBOSE, FREE CALCIUM, OSCILLATIONS, RHYTHMS, CA2+, TRANSCRIPTION, EXPRESSION, CYCLASE, PLANTS

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