The bacterial segrosome: a dynamic nucleoprotein machine for DNA trafficking and segregation

F  Hayes; D  Barilla

doi:10.1038/nrmicro1342

The bacterial segrosome: a dynamic nucleoprotein machine for DNA trafficking and segregation

F Hayes, D Barilla

Biology

Research output: Contribution to journal › Literature review › peer-review

Abstract

The genomes of unicellular and multicellular organisms must be partitioned equitably in coordination with cytokinesis to ensure faithful transmission of duplicated genetic material to daughter cells. Bacteria use sophisticated molecular mechanisms to guarantee accurate segregation of both plasmids and chromosomes at cell division. Plasmid segregation is most commonly mediated by a Walker-type ATPase and one of many DNA-binding proteins that assemble on a cis-acting centromere to form a nucleoprotein complex (the segrosome) that mediates intracellular plasmid transport. Bacterial chromosome segregation involves a multipartite strategy in which several discrete protein complexes potentially participate. Shedding light on the basis of genome segregation in bacteria could indicate new strategies aimed at combating pathogenic and antibiotic-resistant bacteria.

Original language	English
Pages (from-to)	133-143
Number of pages	11
Journal	Nature reviews. Microbiology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1038/nrmicro1342
Publication status	Published - Feb 2006

Keywords

P1 PLASMID-PARTITION
UNIT-COPY MINIPLASMIDS
INTEGRATION HOST FACTOR
CENTRAL CONTROL REGION
REPABC-TYPE REPLICON
PARB HOMOLOG KORB
ATP-BINDING SITE
ESCHERICHIA-COLI
F-PLASMID
DAUGHTER CELLS

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10.1038/nrmicro1342

Cite this

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title = "The bacterial segrosome: a dynamic nucleoprotein machine for DNA trafficking and segregation",

abstract = "The genomes of unicellular and multicellular organisms must be partitioned equitably in coordination with cytokinesis to ensure faithful transmission of duplicated genetic material to daughter cells. Bacteria use sophisticated molecular mechanisms to guarantee accurate segregation of both plasmids and chromosomes at cell division. Plasmid segregation is most commonly mediated by a Walker-type ATPase and one of many DNA-binding proteins that assemble on a cis-acting centromere to form a nucleoprotein complex (the segrosome) that mediates intracellular plasmid transport. Bacterial chromosome segregation involves a multipartite strategy in which several discrete protein complexes potentially participate. Shedding light on the basis of genome segregation in bacteria could indicate new strategies aimed at combating pathogenic and antibiotic-resistant bacteria.",

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author = "F Hayes and D Barilla",

year = "2006",

month = feb,

doi = "10.1038/nrmicro1342",

language = "English",

volume = "4",

pages = "133--143",

journal = "Nature reviews. Microbiology",

issn = "1740-1534",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - The bacterial segrosome: a dynamic nucleoprotein machine for DNA trafficking and segregation

AU - Hayes, F

AU - Barilla, D

PY - 2006/2

Y1 - 2006/2

N2 - The genomes of unicellular and multicellular organisms must be partitioned equitably in coordination with cytokinesis to ensure faithful transmission of duplicated genetic material to daughter cells. Bacteria use sophisticated molecular mechanisms to guarantee accurate segregation of both plasmids and chromosomes at cell division. Plasmid segregation is most commonly mediated by a Walker-type ATPase and one of many DNA-binding proteins that assemble on a cis-acting centromere to form a nucleoprotein complex (the segrosome) that mediates intracellular plasmid transport. Bacterial chromosome segregation involves a multipartite strategy in which several discrete protein complexes potentially participate. Shedding light on the basis of genome segregation in bacteria could indicate new strategies aimed at combating pathogenic and antibiotic-resistant bacteria.

AB - The genomes of unicellular and multicellular organisms must be partitioned equitably in coordination with cytokinesis to ensure faithful transmission of duplicated genetic material to daughter cells. Bacteria use sophisticated molecular mechanisms to guarantee accurate segregation of both plasmids and chromosomes at cell division. Plasmid segregation is most commonly mediated by a Walker-type ATPase and one of many DNA-binding proteins that assemble on a cis-acting centromere to form a nucleoprotein complex (the segrosome) that mediates intracellular plasmid transport. Bacterial chromosome segregation involves a multipartite strategy in which several discrete protein complexes potentially participate. Shedding light on the basis of genome segregation in bacteria could indicate new strategies aimed at combating pathogenic and antibiotic-resistant bacteria.

KW - P1 PLASMID-PARTITION

KW - UNIT-COPY MINIPLASMIDS

KW - INTEGRATION HOST FACTOR

KW - CENTRAL CONTROL REGION

KW - REPABC-TYPE REPLICON

KW - PARB HOMOLOG KORB

KW - ATP-BINDING SITE

KW - ESCHERICHIA-COLI

KW - F-PLASMID

KW - DAUGHTER CELLS

U2 - 10.1038/nrmicro1342

DO - 10.1038/nrmicro1342

M3 - Literature review

SN - 1740-1534

VL - 4

SP - 133

EP - 143

JO - Nature reviews. Microbiology

JF - Nature reviews. Microbiology

IS - 2

ER -