The chemokine receptor D6 limits the inflammatory response in vivo

Thomas Jamieson; Donald N Cook; Robert J B Nibbs; Antal Rot; Colin Nixon; Pauline McLean; Antonio Alcami; Sergio A Lira; Maria Wiekowski; Gerard J Graham

doi:10.1038/ni1182

The chemokine receptor D6 limits the inflammatory response in vivo

Thomas Jamieson, Donald N Cook, Robert J B Nibbs, Antal Rot, Colin Nixon, Pauline McLean, Antonio Alcami, Sergio A Lira, Maria Wiekowski, Gerard J Graham

Research output: Contribution to journal › Article › peer-review

Abstract

How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.

Original language	English
Pages (from-to)	403-11
Number of pages	9
Journal	Nature immunology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/ni1182
Publication status	Published - Apr 2005

Keywords

Animals
Chemokine CXCL2
Chemokines
Chemokines, CC
Dermatitis
Female
Histocytochemistry
Inflammation
Keratins
Mast Cells
Mice
Mice, Inbred C57BL
Mice, Knockout
Proliferating Cell Nuclear Antigen
Psoriasis
Receptors, CCR10
Receptors, Chemokine
Skin
von Willebrand Factor

Access to Document

10.1038/ni1182

Cite this

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title = "The chemokine receptor D6 limits the inflammatory response in vivo",

abstract = "How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.",

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author = "Thomas Jamieson and Cook, {Donald N} and Nibbs, {Robert J B} and Antal Rot and Colin Nixon and Pauline McLean and Antonio Alcami and Lira, {Sergio A} and Maria Wiekowski and Graham, {Gerard J}",

year = "2005",

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T1 - The chemokine receptor D6 limits the inflammatory response in vivo

AU - Jamieson, Thomas

AU - Cook, Donald N

AU - Nibbs, Robert J B

AU - Rot, Antal

AU - Nixon, Colin

AU - McLean, Pauline

AU - Alcami, Antonio

AU - Lira, Sergio A

AU - Wiekowski, Maria

AU - Graham, Gerard J

PY - 2005/4

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N2 - How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.

AB - How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.

KW - Animals

KW - Chemokine CXCL2

KW - Chemokines

KW - Chemokines, CC

KW - Dermatitis

KW - Female

KW - Histocytochemistry

KW - Inflammation

KW - Keratins

KW - Mast Cells

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Proliferating Cell Nuclear Antigen

KW - Psoriasis

KW - Receptors, CCR10

KW - Receptors, Chemokine

KW - Skin

KW - von Willebrand Factor

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DO - 10.1038/ni1182

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JO - Nature immunology

JF - Nature immunology

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