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From the same journal

The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS

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Published copy (DOI)

Author(s)

  • Bohdan Nosyk
  • Huiying Sun
  • Nick Bansback
  • Daphne P. Guh
  • Xin Li
  • Paul Barnett
  • Ahmed Bayoumi
  • Susan Griffin
  • Vilija Joyce
  • Mark Holodniy
  • Doug K. Owens
  • Aslam H. Anis

Department/unit(s)

Publication details

JournalQuality of life research
DatePublished - Sep 2009
Issue number7
Volume18
Number of pages10
Pages (from-to)815-824
Original languageEnglish

Abstract

To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.

Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.

The study enrolled 368 patients (mean follow-up: 3.66 years); 82% had at least one severe adverse event and 27% had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85% of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95%CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).

The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population.

    Research areas

  • Health utilities index, MOS-HIV, EQ-5D, HIV/AIDS, QUALITY-OF-LIFE, HIV-INFECTED PATIENTS, CLINICAL-TRIAL, MEDICAL OUTCOMES, RELIABILITY, MULTIATTRIBUTE, INSTRUMENTS, THERAPY, EUROQOL, DISEASE

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