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The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS

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The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS. / Nosyk, Bohdan; Sun, Huiying; Bansback, Nick; Guh, Daphne P.; Li, Xin; Barnett, Paul; Bayoumi, Ahmed; Griffin, Susan; Joyce, Vilija; Holodniy, Mark; Owens, Doug K.; Anis, Aslam H.

In: Quality of life research, Vol. 18, No. 7, 09.2009, p. 815-824.

Research output: Contribution to journalArticle

Harvard

Nosyk, B, Sun, H, Bansback, N, Guh, DP, Li, X, Barnett, P, Bayoumi, A, Griffin, S, Joyce, V, Holodniy, M, Owens, DK & Anis, AH 2009, 'The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS', Quality of life research, vol. 18, no. 7, pp. 815-824. https://doi.org/10.1007/s11136-009-9504-0

APA

Nosyk, B., Sun, H., Bansback, N., Guh, D. P., Li, X., Barnett, P., ... Anis, A. H. (2009). The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS. Quality of life research, 18(7), 815-824. https://doi.org/10.1007/s11136-009-9504-0

Vancouver

Nosyk B, Sun H, Bansback N, Guh DP, Li X, Barnett P et al. The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS. Quality of life research. 2009 Sep;18(7):815-824. https://doi.org/10.1007/s11136-009-9504-0

Author

Nosyk, Bohdan ; Sun, Huiying ; Bansback, Nick ; Guh, Daphne P. ; Li, Xin ; Barnett, Paul ; Bayoumi, Ahmed ; Griffin, Susan ; Joyce, Vilija ; Holodniy, Mark ; Owens, Doug K. ; Anis, Aslam H. / The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS. In: Quality of life research. 2009 ; Vol. 18, No. 7. pp. 815-824.

Bibtex - Download

@article{d573f57216ce4801b096e04558685171,
title = "The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS",
abstract = "To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.The study enrolled 368 patients (mean follow-up: 3.66 years); 82{\%} had at least one severe adverse event and 27{\%} had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85{\%} of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95{\%}CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population.",
keywords = "Health utilities index, MOS-HIV, EQ-5D, HIV/AIDS, QUALITY-OF-LIFE, HIV-INFECTED PATIENTS, CLINICAL-TRIAL, MEDICAL OUTCOMES, RELIABILITY, MULTIATTRIBUTE, INSTRUMENTS, THERAPY, EUROQOL, DISEASE",
author = "Bohdan Nosyk and Huiying Sun and Nick Bansback and Guh, {Daphne P.} and Xin Li and Paul Barnett and Ahmed Bayoumi and Susan Griffin and Vilija Joyce and Mark Holodniy and Owens, {Doug K.} and Anis, {Aslam H.}",
year = "2009",
month = "9",
doi = "10.1007/s11136-009-9504-0",
language = "English",
volume = "18",
pages = "815--824",
journal = "Quality of life research",
issn = "0962-9343",
publisher = "Springer International Publishing Switzerland",
number = "7",

}

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TY - JOUR

T1 - The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS

AU - Nosyk, Bohdan

AU - Sun, Huiying

AU - Bansback, Nick

AU - Guh, Daphne P.

AU - Li, Xin

AU - Barnett, Paul

AU - Bayoumi, Ahmed

AU - Griffin, Susan

AU - Joyce, Vilija

AU - Holodniy, Mark

AU - Owens, Doug K.

AU - Anis, Aslam H.

PY - 2009/9

Y1 - 2009/9

N2 - To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.The study enrolled 368 patients (mean follow-up: 3.66 years); 82% had at least one severe adverse event and 27% had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85% of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95%CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population.

AB - To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.The study enrolled 368 patients (mean follow-up: 3.66 years); 82% had at least one severe adverse event and 27% had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85% of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95%CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population.

KW - Health utilities index

KW - MOS-HIV

KW - EQ-5D

KW - HIV/AIDS

KW - QUALITY-OF-LIFE

KW - HIV-INFECTED PATIENTS

KW - CLINICAL-TRIAL

KW - MEDICAL OUTCOMES

KW - RELIABILITY

KW - MULTIATTRIBUTE

KW - INSTRUMENTS

KW - THERAPY

KW - EUROQOL

KW - DISEASE

UR - http://www.scopus.com/inward/record.url?scp=69249221348&partnerID=8YFLogxK

U2 - 10.1007/s11136-009-9504-0

DO - 10.1007/s11136-009-9504-0

M3 - Article

VL - 18

SP - 815

EP - 824

JO - Quality of life research

T2 - Quality of life research

JF - Quality of life research

SN - 0962-9343

IS - 7

ER -