The default mode network in cognition: a topographical perspective

Jonathan Smallwood*, Boris C. Bernhardt, Robert Leech, Danilo Bzdok, Elizabeth Jefferies, Daniel S. Margulies

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The default mode network (DMN) is a set of widely distributed brain regions in the parietal, temporal and frontal cortex. These regions often show reductions in activity during attention-demanding tasks but increase their activity across multiple forms of complex cognition, many of which are linked to memory or abstract thought. Within the cortex, the DMN has been shown to be located in regions furthest away from those contributing to sensory and motor systems. Here, we consider how our knowledge of the topographic characteristics of the DMN can be leveraged to better understand how this network contributes to cognition and behaviour.

Original languageEnglish
Pages (from-to)503–513
JournalNature Reviews Neuroscience
Early online date5 Jul 2021
Publication statusPublished - Aug 2021

Bibliographical note

Funding Information:
The authors thank N. Ho for help in the preparation of Supplementary Fig. 1 and R. Braga, L. Lanzoni and D. Vatansever for providing data for use in preparing the figures. The work in this Perspective was supported by consolidator grants from the European Research Council (ERC) (Award 646-927 WANDERINGMINDS to J.S., Award 866533-CORTIGRAD to D.S.M. and Award 771863-FLEXSEM to E.J.). D.B. was supported by the Canada Institute for Advanced Research (CIFAR) Artificial Intelligence Chairs programme, Google and National Institutes of Health (NIH) grant R01AG068563A. R.L. was supported by Wellcome/ Engineering and Physical Sciences Research Council (EPSRC) Centre for Medical Engineering (Ref: WT 203148/Z/16/). B.B. received support from the Natural Sciences and Engineering Research Council of Canada (NSERC) (Discovery-1304413), the Canadian Institutes of Health Research (CIHR FDN-154298, PJT-174995), SickKids Foundation (NI17-039), BrainCanada (Azrieli Future Leaders) and the Tier-2 Canada Research Chairs programme.

Publisher Copyright:
© 2021, Springer Nature Limited.

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