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From the same journal

The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x)

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JournalBioorganic and Medicinal Chemistry
DatePublished - Dec 1998
Issue number12
Volume6
Number of pages19
Pages (from-to)2421-2439
Original languageEnglish

Abstract

The design and synthesis of a series of analogues of sialyl Lewis(x) (1) which incorporate conformationally rigid tetralin and naphthalene ring systems (2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

    Research areas

  • cell adhesion, Sialyl Lewis(x), selectin inhibitors, tetralins, naphthalenes, E-SELECTIN, CELL-ADHESION, X MIMETICS, CARBOHYDRATE LIGAND, INHIBITORS, ACID, MIMICS, RECOGNITION, BLOCKERS, BINDING

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