The effect of parasitization by Leishmania mexicana mexicana on macrophage function in vitro

R S Bray; B Heikal; P M Kaye; M A Bray

The effect of parasitization by Leishmania mexicana mexicana on macrophage function in vitro

R S Bray, B Heikal, P M Kaye, M A Bray

The Hull York Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophages infected with amastigotes of Leishmania mexicana mexicana as compared to normal macrophages show decreased migration both randomly and through a 5 microns pore in response to a known chemotaxin, an increased ability to pinocytose and an increased bactericidal ability. Unless very heavily parasitized their ability to phagocytose is unaltered. Parasitized macrophages are unaltered in their ability to secrete extracellularly lysosomal enzymes, prostaglandins and lysozyme in response to known stimuli, or to kill target cells in an antibody dependent cell mediated cytotoxicity assay.

Original language	English
Pages (from-to)	29-38
Number of pages	10
Journal	Acta tropica
Volume	40
Issue number	1
Publication status	Published - Mar 1983

Keywords

Animals
Antibody-Dependent Cell Cytotoxicity
Blood Bactericidal Activity
Cell Migration Inhibition
In Vitro Techniques
Leishmania
Lysosomes
Macrophages
Mice
Phagocytosis
Pinocytosis

Cite this

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title = "The effect of parasitization by Leishmania mexicana mexicana on macrophage function in vitro",

abstract = "Macrophages infected with amastigotes of Leishmania mexicana mexicana as compared to normal macrophages show decreased migration both randomly and through a 5 microns pore in response to a known chemotaxin, an increased ability to pinocytose and an increased bactericidal ability. Unless very heavily parasitized their ability to phagocytose is unaltered. Parasitized macrophages are unaltered in their ability to secrete extracellularly lysosomal enzymes, prostaglandins and lysozyme in response to known stimuli, or to kill target cells in an antibody dependent cell mediated cytotoxicity assay.",

keywords = "Animals, Antibody-Dependent Cell Cytotoxicity, Blood Bactericidal Activity, Cell Migration Inhibition, In Vitro Techniques, Leishmania, Lysosomes, Macrophages, Mice, Phagocytosis, Pinocytosis",

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year = "1983",

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journal = "Acta tropica",

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T1 - The effect of parasitization by Leishmania mexicana mexicana on macrophage function in vitro

AU - Bray, R S

AU - Heikal, B

AU - Kaye, P M

AU - Bray, M A

PY - 1983/3

Y1 - 1983/3

N2 - Macrophages infected with amastigotes of Leishmania mexicana mexicana as compared to normal macrophages show decreased migration both randomly and through a 5 microns pore in response to a known chemotaxin, an increased ability to pinocytose and an increased bactericidal ability. Unless very heavily parasitized their ability to phagocytose is unaltered. Parasitized macrophages are unaltered in their ability to secrete extracellularly lysosomal enzymes, prostaglandins and lysozyme in response to known stimuli, or to kill target cells in an antibody dependent cell mediated cytotoxicity assay.

AB - Macrophages infected with amastigotes of Leishmania mexicana mexicana as compared to normal macrophages show decreased migration both randomly and through a 5 microns pore in response to a known chemotaxin, an increased ability to pinocytose and an increased bactericidal ability. Unless very heavily parasitized their ability to phagocytose is unaltered. Parasitized macrophages are unaltered in their ability to secrete extracellularly lysosomal enzymes, prostaglandins and lysozyme in response to known stimuli, or to kill target cells in an antibody dependent cell mediated cytotoxicity assay.

KW - Animals

KW - Antibody-Dependent Cell Cytotoxicity

KW - Blood Bactericidal Activity

KW - Cell Migration Inhibition

KW - In Vitro Techniques

KW - Leishmania

KW - Lysosomes

KW - Macrophages

KW - Mice

KW - Phagocytosis

KW - Pinocytosis

M3 - Article

C2 - 6134450

SN - 0001-706X

VL - 40

SP - 29

EP - 38

JO - Acta tropica

JF - Acta tropica

IS - 1

ER -