The epitheliome: agent-based modelling of the social behaviour of cells

D C Walker; J Southgate; G Hill; A Holcombe; D R Hose; S M Wood; S Mac Neil; R H Smallwood

doi:10.1016/j.biosystems.2004.05.025

The epitheliome: agent-based modelling of the social behaviour of cells

D C Walker, J Southgate, G Hill, A Holcombe, D R Hose, S M Wood, S Mac Neil, R H Smallwood

Jack Birch Unit

Research output: Contribution to journal › Article › peer-review

Abstract

We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	89-100
Number of pages	12
Journal	Biosystems
Volume	76
Issue number	1-3
DOIs	https://doi.org/10.1016/j.biosystems.2004.05.025
Publication status	Published - 2004

Keywords

self-organizing systems
agent-based modelling
epithelium
cell culture
calcium
STEM-CELLS
PROLIFERATION
SIMULATION
EPIDERMIS
TISSUE
GROWTH
GENES

Access to Document

10.1016/j.biosystems.2004.05.025

Cite this

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title = "The epitheliome: agent-based modelling of the social behaviour of cells",

abstract = "We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models. (C) 2004 Elsevier Ireland Ltd. All rights reserved.",

keywords = "self-organizing systems, agent-based modelling, epithelium, cell culture, calcium, STEM-CELLS, PROLIFERATION, SIMULATION, EPIDERMIS, TISSUE, GROWTH, GENES",

author = "Walker, {D C} and J Southgate and G Hill and A Holcombe and Hose, {D R} and Wood, {S M} and {Mac Neil}, S and Smallwood, {R H}",

year = "2004",

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language = "English",

volume = "76",

pages = "89--100",

journal = "Biosystems",

issn = "0303-2647",

publisher = "Elsevier",

number = "1-3",

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TY - JOUR

T1 - The epitheliome: agent-based modelling of the social behaviour of cells

AU - Walker, D C

AU - Southgate, J

AU - Hill, G

AU - Holcombe, A

AU - Hose, D R

AU - Wood, S M

AU - Mac Neil, S

AU - Smallwood, R H

PY - 2004

Y1 - 2004

N2 - We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

AB - We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

KW - self-organizing systems

KW - agent-based modelling

KW - epithelium

KW - cell culture

KW - calcium

KW - STEM-CELLS

KW - PROLIFERATION

KW - SIMULATION

KW - EPIDERMIS

KW - TISSUE

KW - GROWTH

KW - GENES

U2 - 10.1016/j.biosystems.2004.05.025

DO - 10.1016/j.biosystems.2004.05.025

M3 - Article

SN - 0303-2647

VL - 76

SP - 89

EP - 100

JO - Biosystems

JF - Biosystems

IS - 1-3

ER -