By the same authors

From the same journal

From the same journal

The epitheliome: agent-based modelling of the social behaviour of cells

Research output: Contribution to journalArticlepeer-review

Author(s)

  • D C Walker
  • J Southgate
  • G Hill
  • A Holcombe
  • D R Hose
  • S M Wood
  • S Mac Neil
  • R H Smallwood

Department/unit(s)

Publication details

JournalBiosystems
DatePublished - 2004
Issue number1-3
Volume76
Number of pages12
Pages (from-to)89-100
Original languageEnglish

Abstract

We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

    Research areas

  • self-organizing systems, agent-based modelling, epithelium, cell culture, calcium, STEM-CELLS, PROLIFERATION, SIMULATION, EPIDERMIS, TISSUE, GROWTH, GENES

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