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The ever changing moods of calmodulin: how structural plasticity entails transductional adaptability

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Alvaro Villarroel
  • Maurizio Taglialatela
  • Ganeko Bernardo-Seisdedos
  • Alessandro Alaimo
  • Jon Agirre
  • Araitz Alberdi
  • Carolina Gomis-Perez
  • Maria Virginia Soldovieri
  • Paolo Ambrosino
  • Covadonga Malo
  • Pilar Areso

Department/unit(s)

Publication details

JournalJournal of Molecular Biology
DatePublished - 29 Jul 2014
Issue number15
Volume426
Number of pages19
Pages (from-to)2717-2735
Original languageEnglish

Abstract

The exceptional versatility of calmodulin (CaM) three-dimensional arrangement is reflected in the growing number of structural models of CaM/protein complexes currently available in the Protein Data Bank (PDB) database, revealing a great diversity of conformations, domain organization, and structural responses to Ca(2+). Understanding CaM binding is complicated by the diversity of target proteins sequences. Data mining of the structures shows that one face of each of the eight CaM helices can contribute to binding, with little overall difference between the Ca(2+) loaded N- and C-lobes and a clear prevalence of the C-lobe low Ca(2+) conditions. The structures reveal a remarkable variety of configurations where CaM binds its targets in a preferred orientation that can be reversed and where CaM rotates upon Ca(2+) binding, suggesting a highly dynamic metastable relation between CaM and its targets. Recent advances in structure-function studies and the discovery of CaM mutations being responsible for human diseases, besides expanding the role of CaM in human pathophysiology, are opening new exciting avenues for the understanding of the how CaM decodes Ca(2+)-dependent and Ca(2+)-independent signals.

Bibliographical note

Copyright © 2014 Elsevier Ltd. All rights reserved.

    Research areas

  • Animals, Calcium Signaling, Calmodulin, Humans, Models, Molecular

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