The first synthesis of the epoxide-containing macrolactone nucleus of oximidine I

J E Harvey, S A Raw, R J K Taylor

Research output: Contribution to journalArticlepeer-review

Abstract

A synthesis of the epoxydiene-containing macrolide nucleus of oximidine I is reported, starting from commercially available 3-butyn-l-ol. The key macrocyclisation step is achieved using Homer-Wadsworth-Emmons methodology in the presence of an epoxide. (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)7209-7212
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number38
DOIs
Publication statusPublished - 15 Sept 2003

Keywords

  • oximidine
  • Horner-Wadsworth-Emmons
  • epoxide
  • FORMAL TOTAL-SYNTHESIS
  • SALICYLIHALAMIDE-A
  • STEREOCONTROLLED SYNTHESIS
  • STEREOSELECTIVE SYNTHESIS
  • ANTITUMOR MACROLIDES
  • ENAMIDES
  • (-)-SALICYLIHALAMIDE-A
  • PRODUCTS

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