The genetic map of Artemisia annua L. identifies multiple loci affecting yield of the antimalarial drug artemisinin

TY - JOUR

T1 - The genetic map of Artemisia annua L. identifies multiple loci affecting yield of the antimalarial drug artemisinin

AU - Graham, Ian A.

AU - Besser, Katrin

AU - Blumer, Susan

AU - Branigan, Caroline A.

AU - Czechowski, Tomasz

AU - Elias, Luisa

AU - Guterman, Inna

AU - Harvey, David

AU - Isaac, Peter G.

AU - Khan, Awais M.

AU - Larson, Tony R.

AU - Li, Yi

AU - Pawson, Tanya

AU - Penfield, Teresa

AU - Rae, Anne M.

AU - Rathbone, Deborah A.

AU - Reid, Sonja

AU - Ross, Joe

AU - Smallwood, Margaret F.

AU - Segura, Vincent

AU - Townsend, Theresa

AU - Vyas, Darshna

AU - Winzer, Thilo

AU - Bowles, Dianna

PY - 2010/1/15

Y1 - 2010/1/15

N2 - Artemisinin is a plant natural product produced by Artemisia annua and the active ingredient in the most effective treatment for malaria. Efforts to eradicate malaria are increasing demand for an affordable, high-quality, robust supply of artemisinin. We performed deep sequencing on the transcriptome of A. annua to identify genes and markers for fast-track breeding. Extensive genetic variation enabled us to build a detailed genetic map with nine linkage groups. Replicated field trials resulted in a quantitative trait loci (QTL) map that accounts for a significant amount of the variation in key traits controlling artemisinin yield. Enrichment for positive QTLs in parents of new high-yielding hybrids confirms that the knowledge and tools to convert A. annua into a robust crop are now available.

AB - Artemisinin is a plant natural product produced by Artemisia annua and the active ingredient in the most effective treatment for malaria. Efforts to eradicate malaria are increasing demand for an affordable, high-quality, robust supply of artemisinin. We performed deep sequencing on the transcriptome of A. annua to identify genes and markers for fast-track breeding. Extensive genetic variation enabled us to build a detailed genetic map with nine linkage groups. Replicated field trials resulted in a quantitative trait loci (QTL) map that accounts for a significant amount of the variation in key traits controlling artemisinin yield. Enrichment for positive QTLs in parents of new high-yielding hybrids confirms that the knowledge and tools to convert A. annua into a robust crop are now available.

KW - BIOSYNTHESIS

KW - ASTERACEAE

KW - CLONING

UR - http://www.scopus.com/inward/record.url?scp=74549123642&partnerID=8YFLogxK

U2 - 10.1126/science.1182612

DO - 10.1126/science.1182612

M3 - Article

SN - 0036-8075

VL - 327

SP - 328

EP - 331

JO - Science

JF - Science

IS - 5963

ER -