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The incorporation of epigenetics in artificial gene regulatory networks

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JournalBiosystems
DatePublished - May 2013
Issue number2
Volume112
Number of pages7
Pages (from-to)56-62
Original languageEnglish

Abstract

Artificial gene regulatory networks are computational models that draw inspiration from biological networks of gene regulation. Since their inception they have been used to infer knowledge about gene regulation and as methods of computation. These computational models have been shown to possess properties typically found in the biological world, such as robustness and self organisation. Recently, it has become apparent that epigenetic mechanisms play an important role in gene regulation. This paper describes a new model, the Artificial Epigenetic Regulatory Network (AERN) which builds upon existing models by adding an epigenetic control layer. Our results demonstrate that AERNs are more adept at controlling multiple opposing trajectories when applied to a chaos control task within a conservative dynamical system, suggesting that AERNs are an interesting area for further investigation.

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© 2013, Elsevier Ireland Ltd.

    Research areas

  • Computational Biology, Computer Simulation, Epigenesis, Genetic, Epigenomics, Gene Regulatory Networks, Models, Genetic, Reproducibility of Results

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