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The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae

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The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae. / Rhodes, Victoria L.; Thomas, Matthew B.; Michel, Kristin.

In: Developmental and Comparative Immunology, Vol. 85, 09.04.2018, p. 125-133.

Research output: Contribution to journalArticlepeer-review

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Rhodes, VL, Thomas, MB & Michel, K 2018, 'The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae', Developmental and Comparative Immunology, vol. 85, pp. 125-133. https://doi.org/10.1016/j.dci.2018.04.008

APA

Rhodes, V. L., Thomas, M. B., & Michel, K. (2018). The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae. Developmental and Comparative Immunology, 85, 125-133. https://doi.org/10.1016/j.dci.2018.04.008

Vancouver

Rhodes VL, Thomas MB, Michel K. The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae. Developmental and Comparative Immunology. 2018 Apr 9;85:125-133. https://doi.org/10.1016/j.dci.2018.04.008

Author

Rhodes, Victoria L. ; Thomas, Matthew B. ; Michel, Kristin. / The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae. In: Developmental and Comparative Immunology. 2018 ; Vol. 85. pp. 125-133.

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@article{44360a35b12b4dca843fa3cd3c02edb4,
title = "The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae",
abstract = "The Toll pathway is a central regulator of antifungal immunity in insects. In mosquitoes, the Toll pathway affects infections with the fungal entomopathogen, Beauveria bassiana, which is considered a potential mosquito biopesticide. We report here the use of B. bassiana strain I93-825 in Anopheles gambiae to analyze the impact of Toll pathway modulation on mosquito survival. Exposure to a narrow dose range of conidia by direct contact decreased mosquito longevity and median survival. In addition, fungal exposure dose correlated positively and linearly with hazard ratio. Increased Toll signaling by knockdown of its inhibitor, cactus, decreased survivorship of uninfected females, increased mosquito survival after low dose B. bassiana exposure, but had little effect following exposure to higher doses. This observed trade-off could have implications for development of B. bassiana as a prospective vector control tool. On the one hand, selection for small increases in mosquito immune signaling across a narrow dose range could impair efficacy of B. bassiana. On the other hand, costs of immunity and the capacity for higher doses of fungus to overwhelm immune responses could limit evolution of resistance.",
keywords = "Beauveria bassiana, Entomopathogenic fungus, Host-pathogen interaction, Innate immunity, Insect vector",
author = "Rhodes, {Victoria L.} and Thomas, {Matthew B.} and Kristin Michel",
year = "2018",
month = apr,
day = "9",
doi = "10.1016/j.dci.2018.04.008",
language = "English",
volume = "85",
pages = "125--133",
journal = "Developmental and Comparative Immunology",
issn = "0145-305X",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae

AU - Rhodes, Victoria L.

AU - Thomas, Matthew B.

AU - Michel, Kristin

PY - 2018/4/9

Y1 - 2018/4/9

N2 - The Toll pathway is a central regulator of antifungal immunity in insects. In mosquitoes, the Toll pathway affects infections with the fungal entomopathogen, Beauveria bassiana, which is considered a potential mosquito biopesticide. We report here the use of B. bassiana strain I93-825 in Anopheles gambiae to analyze the impact of Toll pathway modulation on mosquito survival. Exposure to a narrow dose range of conidia by direct contact decreased mosquito longevity and median survival. In addition, fungal exposure dose correlated positively and linearly with hazard ratio. Increased Toll signaling by knockdown of its inhibitor, cactus, decreased survivorship of uninfected females, increased mosquito survival after low dose B. bassiana exposure, but had little effect following exposure to higher doses. This observed trade-off could have implications for development of B. bassiana as a prospective vector control tool. On the one hand, selection for small increases in mosquito immune signaling across a narrow dose range could impair efficacy of B. bassiana. On the other hand, costs of immunity and the capacity for higher doses of fungus to overwhelm immune responses could limit evolution of resistance.

AB - The Toll pathway is a central regulator of antifungal immunity in insects. In mosquitoes, the Toll pathway affects infections with the fungal entomopathogen, Beauveria bassiana, which is considered a potential mosquito biopesticide. We report here the use of B. bassiana strain I93-825 in Anopheles gambiae to analyze the impact of Toll pathway modulation on mosquito survival. Exposure to a narrow dose range of conidia by direct contact decreased mosquito longevity and median survival. In addition, fungal exposure dose correlated positively and linearly with hazard ratio. Increased Toll signaling by knockdown of its inhibitor, cactus, decreased survivorship of uninfected females, increased mosquito survival after low dose B. bassiana exposure, but had little effect following exposure to higher doses. This observed trade-off could have implications for development of B. bassiana as a prospective vector control tool. On the one hand, selection for small increases in mosquito immune signaling across a narrow dose range could impair efficacy of B. bassiana. On the other hand, costs of immunity and the capacity for higher doses of fungus to overwhelm immune responses could limit evolution of resistance.

KW - Beauveria bassiana

KW - Entomopathogenic fungus

KW - Host-pathogen interaction

KW - Innate immunity

KW - Insect vector

UR - http://www.scopus.com/inward/record.url?scp=85047462256&partnerID=8YFLogxK

U2 - 10.1016/j.dci.2018.04.008

DO - 10.1016/j.dci.2018.04.008

M3 - Article

C2 - 29649553

AN - SCOPUS:85047462256

VL - 85

SP - 125

EP - 133

JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

SN - 0145-305X

ER -