The luminance-response function of the human photopic electroretinogram: a mathematical model

R. Hamilton; M. A. Bees; C. A. Chaplin; D. L. McCulloch

doi:10.1016/j.visres.2007.04.020

The luminance-response function of the human photopic electroretinogram: a mathematical model

R. Hamilton, M. A. Bees, C. A. Chaplin, D. L. McCulloch

Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

The luminance-response function of the brief flash full-field photopic electroretinogram, (ERG) rises to a peak before falling to a submaximal plateau - the 'photopic hill'. The combination of on- and off-responses inherent in the brief flash photopic ERG suggests that this luminance-response function could be modelled by the sum of a Gaussian function and a logistic growth function. Photopic ERGs to a luminance series of brief flashes against three different background luminances recorded from seven healthy adults showed the characteristic 'photopic hill' function for b-wave amplitudes which were satisfactorily fitted with the sum of a Gaussian curve and a logistic growth curve. As background luminance increased, both components shifted to the right on the luminance axis. The Gaussian component increased in amplitude while the logistic growth function component decreased in amplitude. The luminance-response function of a complete congenital stationary night blindness patient had almost no logistic growth component. (c) 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2968-2972
Number of pages	5
Journal	Vision Research
Volume	47
Issue number	23
DOIs	https://doi.org/10.1016/j.visres.2007.04.020
Publication status	Published - Oct 2007

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10.1016/j.visres.2007.04.020

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title = "The luminance-response function of the human photopic electroretinogram: a mathematical model",

abstract = "The luminance-response function of the brief flash full-field photopic electroretinogram, (ERG) rises to a peak before falling to a submaximal plateau - the 'photopic hill'. The combination of on- and off-responses inherent in the brief flash photopic ERG suggests that this luminance-response function could be modelled by the sum of a Gaussian function and a logistic growth function. Photopic ERGs to a luminance series of brief flashes against three different background luminances recorded from seven healthy adults showed the characteristic 'photopic hill' function for b-wave amplitudes which were satisfactorily fitted with the sum of a Gaussian curve and a logistic growth curve. As background luminance increased, both components shifted to the right on the luminance axis. The Gaussian component increased in amplitude while the logistic growth function component decreased in amplitude. The luminance-response function of a complete congenital stationary night blindness patient had almost no logistic growth component. (c) 2007 Elsevier Ltd. All rights reserved.",

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T1 - The luminance-response function of the human photopic electroretinogram

T2 - a mathematical model

AU - Hamilton, R.

AU - Bees, M. A.

AU - Chaplin, C. A.

AU - McCulloch, D. L.

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AB - The luminance-response function of the brief flash full-field photopic electroretinogram, (ERG) rises to a peak before falling to a submaximal plateau - the 'photopic hill'. The combination of on- and off-responses inherent in the brief flash photopic ERG suggests that this luminance-response function could be modelled by the sum of a Gaussian function and a logistic growth function. Photopic ERGs to a luminance series of brief flashes against three different background luminances recorded from seven healthy adults showed the characteristic 'photopic hill' function for b-wave amplitudes which were satisfactorily fitted with the sum of a Gaussian curve and a logistic growth curve. As background luminance increased, both components shifted to the right on the luminance axis. The Gaussian component increased in amplitude while the logistic growth function component decreased in amplitude. The luminance-response function of a complete congenital stationary night blindness patient had almost no logistic growth component. (c) 2007 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.visres.2007.04.020

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