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From the same journal

The manipulation of calcium oscillations by harnessing self-organisation

Research output: Contribution to journalArticlepeer-review



Publication details

DatePublished - Oct 2008
Issue number1-2
Number of pages11
Pages (from-to)153-63
Original languageEnglish


This paper investigates how self-organisation might be harnessed for the manipulation and control of calcium oscillations. Calcium signalling mechanisms are responsible for a number of important functions within biological systems, such as fertilization, secretion, contraction, neuronal signalling and learning. In this paper, calcium oscillations are investigated as a biological periodic process. Within biological systems such periodic behaviour is one of the outcomes from self-organisation. The understanding of periodic processes in living systems can enable more accurate diagnosis and physiologically suitable clinical therapies to be proposed, for diseases such as cancer, epilepsy, cardiac diseases and other dynamic diseases. In this paper these ideas are investigated by means of the calcium-induced calcium release (CICR) model and a number of representative simulations of intra and inter-cellular calcium oscillations are used to illustrate the manipulation and control of these oscillations in normal and pathological situations.

    Research areas

  • Self-organisation, Synchronisation, Calcium dynamics, CICR model, Chemical oscillations, Dynamic diseases, RAT HEPATOCYTES, WAVES, PROPAGATION, CHANNELS, SIGNAL, MODEL

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