The oncogenic potential of Candida in the female genital tract

C.J.N. Lacey; S. Dutton; R.A. Smith; R.M. Walmsley; B.M. Wilkinson; E.G.V. Evans; C.A. Hitchcock; D.J. Adams

The oncogenic potential of Candida in the female genital tract

C.J.N. Lacey, S. Dutton, R.A. Smith, R.M. Walmsley, B.M. Wilkinson, E.G.V. Evans, C.A. Hitchcock, D.J. Adams

Research output: Contribution to journal › Article › peer-review

Abstract

The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.

Original language	English
Pages (from-to)	8-14
Number of pages	7
Journal	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Volume	5
Issue number	1
Publication status	Published - 1995

Cite this

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title = "The oncogenic potential of Candida in the female genital tract",

abstract = "The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.",

author = "C.J.N. Lacey and S. Dutton and R.A. Smith and R.M. Walmsley and B.M. Wilkinson and E.G.V. Evans and C.A. Hitchcock and D.J. Adams",

year = "1995",

language = "English",

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journal = "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",

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T1 - The oncogenic potential of Candida in the female genital tract

AU - Lacey, C.J.N.

AU - Dutton, S.

AU - Smith, R.A.

AU - Walmsley, R.M.

AU - Wilkinson, B.M.

AU - Evans, E.G.V.

AU - Hitchcock, C.A.

AU - Adams, D.J.

PY - 1995

Y1 - 1995

N2 - The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.

AB - The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.

M3 - Article

C2 - 11578446

SN - 1525-1438

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JO - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

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