The Organization of the Visual Cortex in Patients with Scotomata Resulting from Lesions of the Central Retina

Heidi A. Baseler; Andre Gouws; Antony B. Morland

doi:10.1080/01658100903050053

The Organization of the Visual Cortex in Patients with Scotomata Resulting from Lesions of the Central Retina

Heidi A. Baseler, Andre Gouws, Antony B. Morland

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Primary visual cortex can undergo forms of reorganization following bilateral lesions to the retinas of animals. Brain cells that originally received input from retinal tissue that was lesioned become responsive to retina that remains intact. In humans, reorganization of the primary visual cortex has been found in adult patients with congenital foveal lesions. More recent investigations of patients with macular degeneration, who acquired retinal lesions later, have yielded mixed results. In this paper we review the evidence for and characteristics of cortical reorganization in humans and animals and suggest how it might be evaluated in the context of strategies for treating retinal disease.

Original language	English
Pages (from-to)	149-157
Number of pages	9
Journal	Neuro-Ophthalmology
Volume	33
Issue number	3
DOIs	https://doi.org/10.1080/01658100903050053
Publication status	Published - Jun 2009

Keywords

Macular degeneration
retinotopy
visual cortex
reorganization
plasticity
TRANSCRANIAL MAGNETIC STIMULATION
MACULAR DEGENERATION
FUNCTIONAL MRI
INDUCED PHOSPHENES
CORTICAL DYNAMICS
BLIND SUBJECTS
NEGATIVE BOLD
HUMAN BRAIN
REORGANIZATION
MONKEY

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10.1080/01658100903050053

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abstract = "Primary visual cortex can undergo forms of reorganization following bilateral lesions to the retinas of animals. Brain cells that originally received input from retinal tissue that was lesioned become responsive to retina that remains intact. In humans, reorganization of the primary visual cortex has been found in adult patients with congenital foveal lesions. More recent investigations of patients with macular degeneration, who acquired retinal lesions later, have yielded mixed results. In this paper we review the evidence for and characteristics of cortical reorganization in humans and animals and suggest how it might be evaluated in the context of strategies for treating retinal disease.",

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N2 - Primary visual cortex can undergo forms of reorganization following bilateral lesions to the retinas of animals. Brain cells that originally received input from retinal tissue that was lesioned become responsive to retina that remains intact. In humans, reorganization of the primary visual cortex has been found in adult patients with congenital foveal lesions. More recent investigations of patients with macular degeneration, who acquired retinal lesions later, have yielded mixed results. In this paper we review the evidence for and characteristics of cortical reorganization in humans and animals and suggest how it might be evaluated in the context of strategies for treating retinal disease.

AB - Primary visual cortex can undergo forms of reorganization following bilateral lesions to the retinas of animals. Brain cells that originally received input from retinal tissue that was lesioned become responsive to retina that remains intact. In humans, reorganization of the primary visual cortex has been found in adult patients with congenital foveal lesions. More recent investigations of patients with macular degeneration, who acquired retinal lesions later, have yielded mixed results. In this paper we review the evidence for and characteristics of cortical reorganization in humans and animals and suggest how it might be evaluated in the context of strategies for treating retinal disease.

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KW - FUNCTIONAL MRI

KW - INDUCED PHOSPHENES

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KW - BLIND SUBJECTS

KW - NEGATIVE BOLD

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The Organization of the Visual Cortex in Patients with Scotomata Resulting from Lesions of the Central Retina

Abstract

Keywords

Access to Document

Other files and links

Plasticity and stability in human foveal pathways

The effects of macular degeneration on the eye, brain and behaviour

Cite this

The Organization of the Visual Cortex in Patients with Scotomata Resulting from Lesions of the Central Retina

Abstract

Keywords

Access to Document

Other files and links

Activities

Plasticity and stability in human foveal pathways

The effects of macular degeneration on the eye, brain and behaviour

Cite this