The pathways of complement

Jonathan M. Aitken; Tim Clarke; Jonathan I. Timmis

doi:10.1007/978-3-540-85072-4_32

The pathways of complement

Jonathan M. Aitken, Tim Clarke, Jonathan I. Timmis

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.

Original language	English
Title of host publication	Lecture Notes in Computer Science
Subtitle of host publication	Artificial Immune Systems
Publisher	Springer
Pages	364-375
Number of pages	12
Volume	5132
ISBN (Electronic)	978-3-540-85072-4
ISBN (Print)	978-3-540-85071-7
DOIs	https://doi.org/10.1007/978-3-540-85072-4_32
Publication status	Published - 2008
Event	7th International Conference on Artificial Immune Systems (ICARIS) - , United Kingdom Duration: 1 Aug 2008 → …

Conference

Conference	7th International Conference on Artificial Immune Systems (ICARIS)
Country/Territory	United Kingdom
Period	1/08/08 → …

Bibliographical note

7th International Conference, ICARIS 2008, Phuket, Thailand, August 10-13, 2008. Proceedings.

Keywords

MANNAN-BINDING LECTIN
ALTERNATIVE PATHWAY
FACTOR-H
SIALIC-ACID
PATTERN-RECOGNITION
C3 CONVERTASE
SYSTEM
ACTIVATION
BETA-1H
PROTEIN

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10.1007/978-3-540-85072-4_32

Cite this

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title = "The pathways of complement",

abstract = "The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.",

keywords = "MANNAN-BINDING LECTIN, ALTERNATIVE PATHWAY, FACTOR-H, SIALIC-ACID, PATTERN-RECOGNITION, C3 CONVERTASE, SYSTEM, ACTIVATION, BETA-1H, PROTEIN",

author = "Aitken, {Jonathan M.} and Tim Clarke and Timmis, {Jonathan I.}",

note = "7th International Conference, ICARIS 2008, Phuket, Thailand, August 10-13, 2008. Proceedings.; 7th International Conference on Artificial Immune Systems (ICARIS) ; Conference date: 01-08-2008",

year = "2008",

doi = "10.1007/978-3-540-85072-4_32",

language = "English",

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TY - GEN

T1 - The pathways of complement

AU - Aitken, Jonathan M.

AU - Clarke, Tim

AU - Timmis, Jonathan I.

N1 - 7th International Conference, ICARIS 2008, Phuket, Thailand, August 10-13, 2008. Proceedings.

PY - 2008

Y1 - 2008

N2 - The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.

AB - The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.

KW - MANNAN-BINDING LECTIN

KW - ALTERNATIVE PATHWAY

KW - FACTOR-H

KW - SIALIC-ACID

KW - PATTERN-RECOGNITION

KW - C3 CONVERTASE

KW - SYSTEM

KW - ACTIVATION

KW - BETA-1H

KW - PROTEIN

UR - http://www.scopus.com/inward/record.url?scp=51049110768&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-85072-4_32

DO - 10.1007/978-3-540-85072-4_32

M3 - Conference contribution

SN - 978-3-540-85071-7

VL - 5132

SP - 364

EP - 375

BT - Lecture Notes in Computer Science

PB - Springer

T2 - 7th International Conference on Artificial Immune Systems (ICARIS)

Y2 - 1 August 2008

ER -

The pathways of complement

Abstract

Conference

Bibliographical note

Keywords

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