The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

The Premenopausal Breast Cancer Collaborative Group

Research output: Contribution to journalReview articlepeer-review


Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual studies and resulting low statistical power to subcategorize exposures or to study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established to facilitate cohort-based analyses of risk factors for premenopausal breast cancer by pooling individual-level data from studies participating in the United States National Cancer Institute Cohort Consortium. This article describes the Group, including the rationale for its initial aims related to pregnancy, obesity, and physical activity. We also describe the 20 cohort studies with data submitted to the Group by June 2016. The infrastructure developed for this work can be leveraged to support additional investigations. Cancer Epidemiol Biomarkers Prev; 26(9); 1360-9. ©2017 AACR.

Original languageEnglish
Pages (from-to)1360-1369
Number of pages10
JournalCancer Epidemiology Biomarkers & Prevention
Issue number9
Early online date9 Jun 2017
Publication statusPublished - Sept 2017

Bibliographical note

©2017 American Association for Cancer Research.


  • Adult
  • Breast Neoplasms
  • Cohort Studies
  • Female
  • Humans
  • Middle Aged
  • National Cancer Institute (U.S.)
  • Premenopause
  • United States

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