By the same authors

From the same journal

The Preparation of Substituted Pyrazoles from beta,beta-Dibromo-enones by a Tandem Condensation/Suzuki-Miyaura Cross-Coupling Process

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Publication details

JournalSynlett
DatePublished - Mar 2010
Issue number4
Number of pages5
Pages (from-to)602-606
Original languageEnglish

Abstract

Two consecutive tandem processes are described for the regioselective, two-step synthesis of 1,3,5-trisubstituted pyrazoles from alpha-hydroxyketones. The first, a tandem MnO2-mediated oxidation/Ramirez olefination reaction, provides a facile route to beta,beta-dibromo-enones. These valuable 1,3-dicarbonyl synthons can then be converted into 1,3,5-trisubstituted pyrazoles via a second tandem hydrazine condensation/Suzuki-Miyaura cross-coupling reaction. Using these procedures, a range of aryl and alkyl alpha-hydroxyketones have been transformed regioselectively into 1,3,5-trisubstituted pyrazoles.

    Research areas

  • tandem oxidation process, TOP, beta,beta-dibromo-enones, 1,3,5-trisubstituted pyrazoles, Suzuki-Miyaura, ONE-POT CONVERSION, OXIDATION PROCESSES, MANGANESE-DIOXIDE, KETONES, 1,1-DIBROMO-1-ALKENES, DERIVATIVES, ALKYNES

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